WEKO3
アイテム
{"_buckets": {"deposit": "ce19203e-4895-4cb9-995a-47e81de4e424"}, "_deposit": {"created_by": 1, "id": "22268", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "22268"}, "status": "published"}, "_oai": {"id": "oai:kumadai.repo.nii.ac.jp:00022268", "sets": ["349"]}, "author_link": ["96828", "96829", "96827"], "item_14_alternative_title_22": {"attribute_name": "その他の言語のタイトル", "attribute_value_mlt": [{"subitem_alternative_title": "Impairment of R5 HIV-1 infectivity due to virion incorporated CCR5"}]}, "item_14_alternative_title_23": {"attribute_name": "タイトル(ヨミ)", "attribute_value_mlt": [{"subitem_alternative_title": "ウイルス リュウシ エノ CCR5 ノ トリコミ ニ ヨル R5 HIV-1 ノ カンセンセイ テイカ"}]}, "item_14_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2008-03-25", "bibliographicIssueDateType": "Issued"}, "bibliographic_titles": [{}]}]}, "item_14_creator_3": {"attribute_name": "別言語の著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Monde, Kazuaki"}], "nameIdentifiers": [{"nameIdentifier": "96829", "nameIdentifierScheme": "WEKO"}]}]}, "item_14_description_17": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}, {"subitem_description": "application/pdf", "subitem_description_type": "Other"}, {"subitem_description": "text/plain", "subitem_description_type": "Other"}]}, "item_14_description_46": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "学位論文(Thesis)", "subitem_description_type": "Other"}]}, "item_14_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Entry of R5 human immunodeficiency virus type 1 (HIV-1) into target cells requires sequential interactions of the envelope glycoprotein gp120 with the receptor CD4 and the coreceptor CCR5. I investigated replication of 45 R5 viral clones derived from the HIV-IJR-FLan library carrying 0-10 random amino acid substitutions in the gp120 V3 loop, and found that 6.7% (3/45) of the viruses revealed MO-fold replication suppression in PM1/CCR5 cells expressing high levels of CCR5 compared to PM1 cells expressing low levels of CCR5.", "subitem_description_type": "Other"}, {"subitem_description": "本研究ではCCR5と直接相互作用するgp120のV3loopに0-10個のアミノ酸置換の組み合わせを持つHIV-1 JR-FLanライブラリーを使い、 V3領域の配列が異なる45種\n類のR5 HIV-1クローンを分離し、CCR5低発現CD4+T細胞PM1と高発現細胞PM1/CCR5でその複製能を比較した。", "subitem_description_type": "Other"}]}, "item_14_publisher_36": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "熊本大学"}]}, "item_14_subject_20": {"attribute_name": "日本十進分類法", "attribute_value_mlt": [{"subitem_subject": "377.5", "subitem_subject_scheme": "NDC"}]}, "item_14_text_18": {"attribute_name": "形態", "attribute_value_mlt": [{"subitem_text_value": "2244376 bytes"}, {"subitem_text_value": "60936 bytes"}, {"subitem_text_value": "72278 bytes"}]}, "item_14_text_47": {"attribute_name": "資源タイプ・ローカル", "attribute_value_mlt": [{"subitem_text_value": "博士論文"}]}, "item_14_text_48": {"attribute_name": "資源タイプ・NII", "attribute_value_mlt": [{"subitem_text_value": "Thesis or Dissertation"}]}, "item_14_text_49": {"attribute_name": "資源タイプ・DCMI", "attribute_value_mlt": [{"subitem_text_value": "text"}]}, "item_14_text_50": {"attribute_name": "資源タイプ・ローカル表示コード", "attribute_value_mlt": [{"subitem_text_value": "03"}]}, "item_14_text_76": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_text_value": "http://hdl.handle.net/2298/11108"}]}, "item_14_text_81": {"attribute_name": "学位番号", "attribute_value_mlt": [{"subitem_text_value": "甲博医第1644号"}]}, "item_14_version_type_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_970fb48d4fbd8a85", "subitem_version_type": "VoR"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "門出 和精"}], "nameIdentifiers": [{"nameIdentifier": "96827", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "22-1644.pdf", "filesize": [{"value": "2.2 MB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 2200000.0, "url": {"label": "22-1644.pdf", "url": "https://kumadai.repo.nii.ac.jp/record/22268/files/22-1644.pdf"}, "version_id": "4b767a9a-37fb-4dfd-aae2-e177a49e67c2"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "R5 HIV-1", "subitem_subject_scheme": "Other"}, {"subitem_subject": "エンベロープタンパク質(Env)", "subitem_subject_scheme": "Other"}, {"subitem_subject": "gp120", "subitem_subject_scheme": "Other"}, {"subitem_subject": "CD4", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HIV-1JR-FLanライブラリー", "subitem_subject_scheme": "Other"}, {"subitem_subject": "HIV-1V3L#08", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "jpn"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "thesis", "resourceuri": "http://purl.org/coar/resource_type/c_46ec"}]}, "item_title": "ウイルス粒子へのCCR5の取り込みによるR5 HIV-1の感染性低下", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "ウイルス粒子へのCCR5の取り込みによるR5 HIV-1の感染性低下"}]}, "item_type_id": "14", "owner": "1", "path": ["349"], "permalink_uri": "http://hdl.handle.net/2298/11108", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-08-12"}, "publish_date": "2014-08-12", "publish_status": "0", "recid": "22268", "relation": {}, "relation_version_is_last": true, "title": ["ウイルス粒子へのCCR5の取り込みによるR5 HIV-1の感染性低下"], "weko_shared_id": -1}
ウイルス粒子へのCCR5の取り込みによるR5 HIV-1の感染性低下
http://hdl.handle.net/2298/11108
http://hdl.handle.net/2298/11108bab60474-6b91-4b2a-8b46-95d84a36f7eb
名前 / ファイル | ライセンス | アクション |
---|---|---|
22-1644.pdf (2.2 MB)
|
|
Item type | 学位論文 / Thesis or Dissertation(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2014-08-12 | |||||
タイトル | ||||||
タイトル | ウイルス粒子へのCCR5の取り込みによるR5 HIV-1の感染性低下 | |||||
言語 | ||||||
言語 | jpn | |||||
キーワード | ||||||
主題 | R5 HIV-1, エンベロープタンパク質(Env), gp120, CD4, HIV-1JR-FLanライブラリー, HIV-1V3L#08 | |||||
資源タイプ | ||||||
資源タイプ | thesis | |||||
著者 |
門出 和精
× 門出 和精 |
|||||
別言語の著者 |
Monde, Kazuaki
× Monde, Kazuaki |
|||||
内容記述 | ||||||
内容記述 | Entry of R5 human immunodeficiency virus type 1 (HIV-1) into target cells requires sequential interactions of the envelope glycoprotein gp120 with the receptor CD4 and the coreceptor CCR5. I investigated replication of 45 R5 viral clones derived from the HIV-IJR-FLan library carrying 0-10 random amino acid substitutions in the gp120 V3 loop, and found that 6.7% (3/45) of the viruses revealed MO-fold replication suppression in PM1/CCR5 cells expressing high levels of CCR5 compared to PM1 cells expressing low levels of CCR5. | |||||
内容記述 | ||||||
内容記述 | 本研究ではCCR5と直接相互作用するgp120のV3loopに0-10個のアミノ酸置換の組み合わせを持つHIV-1 JR-FLanライブラリーを使い、 V3領域の配列が異なる45種 類のR5 HIV-1クローンを分離し、CCR5低発現CD4+T細胞PM1と高発現細胞PM1/CCR5でその複製能を比較した。 |
|||||
書誌情報 | 発行年 2008-03-25 | |||||
フォーマット | ||||||
内容記述 | application/pdf, application/pdf, text/plain | |||||
形態 | ||||||
2244376 bytes, 60936 bytes, 72278 bytes | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
日本十進分類法 | ||||||
主題 | 377.5 | |||||
その他の言語のタイトル | ||||||
その他のタイトル | Impairment of R5 HIV-1 infectivity due to virion incorporated CCR5 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | ウイルス リュウシ エノ CCR5 ノ トリコミ ニ ヨル R5 HIV-1 ノ カンセンセイ テイカ | |||||
出版者 | ||||||
出版者 | 熊本大学 | |||||
資源タイプ | ||||||
内容記述 | 学位論文(Thesis) | |||||
資源タイプ・ローカル | ||||||
博士論文 | ||||||
資源タイプ・NII | ||||||
Thesis or Dissertation | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
03 | ||||||
学位番号 | ||||||
甲博医第1644号 |