Cell division relies on the activation of cyclins, which bind to cyclin-dependent kinases (CDKs) to induce cell cycle progression towards S phase and later to initiate mitosis. Since uncontrolled cyclin-dependent kinase activity is often the cause of human cancer, their function is tightly regulated by cell-cycle inhibitors such as the p21 and p27 Cip/Kip proteins. Following anti-mitogenic signals or DNA damage, p21 and p27 bind to cyclin-CDK complexes to inhibit their catalytic activity and induce cell-cycle arrest. Interestingly, recent discoveries suggest that p21 and p27 might have new activities that are unrelated to their function as CDK inhibitors. The identification of new targets of Cip/Kip proteins as well as evidence of Cip/Kip cytoplasmic relocalization have revealed unexpected functions of these proteins in the regulation of apoptosis. This article discusses recent insights into this possible additional functions of p21 and p27.
雑誌名
熊本大学医学部保健学科紀要
巻
7
ページ
1 - 9
発行年
2011-03-23
ISSN
18807151
書誌レコードID
AA12010572
フォーマット
application/pdf
形態
1537301 bytes
著者版フラグ
publisher
日本十進分類法
463.6
その他の言語のタイトル
Cyclin-dependent kinase inhibitors in the regulation of apoptosis
CDKインヒビターによるアポトーシス制御
MH0007_001-0009.pdf
(1.54MB)
