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Study of draxin and Tsukushi function in brain development and injury
http://hdl.handle.net/2298/28604
http://hdl.handle.net/2298/28604d613e349-826e-43f7-985b-69d48392e2c1
名前 / ファイル | ライセンス | アクション |
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51-0016.pdf (21.5 MB)
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Item type | 学位論文 / Thesis or Dissertation(1) | |||||
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公開日 | 2013-07-24 | |||||
タイトル | ||||||
タイトル | Study of draxin and Tsukushi function in brain development and injury | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | thesis | |||||
著者 |
Mahmud Hossain
× Mahmud Hossain |
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別言語の著者 |
マームド ホセイン
× マームド ホセイン |
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内容記述 | ||||||
内容記述 | Background and Purpose: Previously we reported the identification of two secreted proteins: draxin and Tsukushi (TSK). Draxin knockout mice showed agenesis of all forebrain commissures: corpus callosum (CC), hippocampal commissure (HC), and anterior commissure (AC). Moreover, genetic deletion of TSK in mice also results in the agenesis of AC and CC, also suggesting the importance of TSK function in forebrain commissure formation. As both draxin and TSK single mutant mice converge into common phenotypes, there is a possibility that the combined function of these two proteins is essential for the formation of forebrain commissures. Furthermore, we documented that draxin exerts its chemorepulsive function through netrin’s chemoattractive receptor, DCC. As different ligands interacted with the same receptor, DCC and shows opposite functions of axon guidance, there might be some other molecule(s) that also interact with DCC to perform the opposite signaling pathway. Additionally, we also tried to explore the function of draxin after brain injury. |
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書誌情報 | 発行年 2012-09-25 | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
形態 | ||||||
21526595 bytes | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
日本十進分類法 | ||||||
主題 | 377.5 | |||||
その他の言語のタイトル | ||||||
その他のタイトル | 脳発生と障害におけるdraxinとTsukushiの果たす機能解析 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | ノウ ハッセイ ト ショウガイ ニ オケル draxin ト Tsukushi ノ ハタス キノウ カイセキ | |||||
出版者 | ||||||
出版者 | 熊本大学 | |||||
資源タイプ | ||||||
内容記述 | 学位論文(Thesis) | |||||
資源タイプ・ローカル | ||||||
博士論文 | ||||||
資源タイプ・NII | ||||||
Thesis or Dissertation | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
03 | ||||||
コメント | ||||||
熊本大学大学院医学教育部 医学専攻 | ||||||
学位番号 | ||||||
甲博生命第16号 |