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Therapeutic effects of γ-irradiation in a primary effusion lymphoma mouse model
http://hdl.handle.net/2298/36143
http://hdl.handle.net/2298/3614395a0ade9-c7f7-4f17-824b-5d545531f5bb
名前 / ファイル | ライセンス | アクション |
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78.Shiraishi-r.pdf (523.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-02-16 | |||||
タイトル | ||||||
タイトル | Therapeutic effects of γ-irradiation in a primary effusion lymphoma mouse model | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | primary effussion lymphoma, radiosensitivity, animal model | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
白石, 善興
× 白石, 善興× 後藤, 久美子× Towata, Tomomi× Shimasaki, Tatsuya× Suzu, Shinya× 古嶋, 昭博× 岡田, 誠治 |
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別言語の著者 |
白石, 善興
× 白石, 善興× 後藤, 久美子× 島﨑, 達也× 鈴, 伸也× 古嶋, 昭博× 岡田, 誠治 |
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内容記述 | ||||||
内容記述 | Primary effusion lymphoma (PEL) is a unique and recently identified non-Hodgkin's lymphoma in immuno-compromised individuals. PEL is caused by the Kaposi sarcoma-associated herpes virus/human herpes virus 8 (KSHV/HHV-8) and has a peculiar presentation involving liquid growth in the serous body cavity, chemotherapy resistance and poor prognosis. In search of a new therapeutic modality for PEL, we examined the effect of γ-irradiation on PEL-derived cell lines (BCBL-1, BC-1, and BC-3) in vitro and in vivo. An MTT assay and trypan blue exclusion assay revealed that irradiation significantly suppressed cell proliferation in the PEL cell lines in a dose-dependent manner, and induced apoptosis. The PEL cell lines were relatively radiosensitive compared with other hematological tumor cell lines (Raji, Jurkat, and K562 cells). Inoculation of the BC‑3 cell line into the peritoneal cavity of Rag2/Jak3 double-deficient mice led to massive ascites formation, and subcutaneous injection of BCBL-1 led to solid lymphoma formation. Total body irradiation (4 Gy x 2) with bone marrow transplantation resulted in the complete recovery of both types of PEL-inoculated mice. These results suggest that total body irradiation with bone marrow transplantation can be successfully applied for the treatment of chemotherapyresistant PEL. | |||||
書誌情報 |
EXPERIMENTAL AND THERAPEUTIC MEDICINE 巻 1, 号 1(January-February 2010), p. 79-84, 発行年 2010-01 |
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DOI | ||||||
関連タイプ | isIdenticalTo | |||||
関連識別子 | 10.3892/etm_00000014 | |||||
情報源(ISSN) | ||||||
関連名称 | 17920981 | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
形態 | ||||||
523495 bytes | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
日本十進分類法 | ||||||
主題 | 492 | |||||
出版者 | ||||||
出版者 | Spandidos Publications | |||||
資源タイプ | ||||||
内容記述 | 論文(Article) | |||||
資源タイプ・ローカル | ||||||
雑誌掲載論文 | ||||||
資源タイプ・NII | ||||||
Journal Article | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
01 | ||||||
URL | ||||||
内容記述 | https://www.spandidos-publications.com/etm/1/1/79 |