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Potential use of iontophoresis for transdermal delivery of NF-κB decoy oligonucleotides
http://hdl.handle.net/2298/16952
http://hdl.handle.net/2298/16952a1b4edfa-113c-4182-8803-17a42ee6b19a
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Iontophoresis-Table-submit-R1.pdf (57.5 kB)
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Iontophoresis-Fig-submit-R1.pdf (165.7 kB)
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NF-kB decoy-submit-R1.pdf (192.3 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2010-11-22 | |||||
タイトル | ||||||
タイトル | Potential use of iontophoresis for transdermal delivery of NF-κB decoy oligonucleotides | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Iontophoresis, NF-κB decoy, Oligonucleotides, Transdermal delivery, Skin inflammation | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
Abu Hashim, Irhan Ibrahim,
× Abu Hashim, Irhan Ibrahim,× Motoyama, Keiichi× Helmy Abd-ElGawad, Abd-ElGawad× H. El-Shabouri, Mohamed× Thanaa Mohamed Borg× Arima, Hidetoshi |
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別言語の著者 |
本山, 敬一
× 本山, 敬一× 有馬, 英俊 |
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内容記述 | ||||||
内容記述 | Topical application of nuclear factor-κB (NF-κB) decoy appears to provide a novel therapeutic potency in the treatment of inflammation and atopic dermatitis. However, it is difficult to deliver NF-κB decoy oligonucleotides (ODN) into the skin by conventional methods based on passive diffusion because of its hydrophilicity and high molecular weight. In this study, we evaluated the in vitro transdermal delivery of fluorescein isothiocyanate (FITC)-NF-κB decoy ODN using a pulse depolarization (PDP) iontophoresis. In vitro iontophoretic experiments were performed on isolated C57BL/6 mice skin using a horizontal diffusion cell. The apparent flux values of FITC-NF-κB decoy ODN were enhanced with increasing the current density and NF-κB decoy ODN concentration by iontophoresis. Accumulation of FITC-NF-κB decoy ODN was observed at the epidermis and upper dermis by iontophoresis. In mouse model of skin inflammation, iontophoretic delivery of NF-κB decoy ODN significantly reduced the increase in ear thickness caused by phorbol ester as well as the protein and mRNA expression levels of tumor necrosis factor-α (TNF-α) in the mice ears. These results suggest that iontophoresis is a useful and promising enhancement technique for transdermal delivery of NF-κB decoy ODN. | |||||
書誌情報 |
International Journal of Pharmaceutics 巻 393, 号 1-2, p. 127-134, 発行年 2010-06 |
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DOI | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 10.1016/j.ijpharm.2010.04.020 | |||||
権利 | ||||||
権利情報 | © 2010 Elsevier B.V. | |||||
情報源(ISSN) | ||||||
関連名称 | 03785173 | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
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内容記述 | application/pdf | |||||
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内容記述 | application/pdf | |||||
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192322 bytes | ||||||
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57478 bytes | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
日本十進分類法 | ||||||
主題 | 499 | |||||
出版者 | ||||||
出版者 | Elsevier B.V. | |||||
資源タイプ | ||||||
内容記述 | 論文(Article) | |||||
資源タイプ・ローカル | ||||||
雑誌掲載論文 | ||||||
資源タイプ・NII | ||||||
Journal Article | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
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URL | ||||||
内容記述 | https://www.sciencedirect.com/science/article/pii/S0378517310002929?via%3Dihub |