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Antidepressant-like effect of centrally acting non-narcotic antitussive caramiphen in a forced swimming test
http://hdl.handle.net/2298/18900
http://hdl.handle.net/2298/18900b78ddddd-0b4a-4479-8e72-253b5e4388cf
名前 / ファイル | ライセンス | アクション |
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NL_481_3_188-190.pdf (200.9 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2011-05-18 | |||||
タイトル | ||||||
タイトル | Antidepressant-like effect of centrally acting non-narcotic antitussive caramiphen in a forced swimming test | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Antidepressant-like effect, Antitussives, Caramiphen, Forced swimming test, G-protein-coupled inwardly rectifying K+ (GIRK) channel | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
川浦, 一晃
× 川浦, 一晃× 三木, 理沙× 島, 絵里子× 本田, 宗吉× 副田, 二三夫× 白崎, 哲哉× 高濱, 和夫 |
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別言語の著者 |
川浦, 一晃
× 川浦, 一晃× 三木, 理沙× 島, 絵里子× 本田, 宗吉× 副田, 二三夫× 白崎, 哲哉× 高濱, 和夫 |
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内容記述 | ||||||
内容記述 | Recently, we reported that a centrally acting non-narcotic antitussive (cough suppressant drug), tipepidine produces an antidepressant-like effect in the forced swimming test in rats. Because pharmacological properties of tipepidine apparently differ from those of typical antidepressants developed to date, we speculated that caramiphen, another centrally acting antitussive, has an antidepressant-like effect. That effect of caramiphen was studied in rats using the forced swimming test. Caramiphen at 20 and 40 mg/kg i.p. significantly reduced immobility. At 40 mg /kg i.p., it increased climbing behavior. Even at 40 mg /kg, this drug had no effect on locomotor activity. Results suggest that a centrally acting antitussive possessing inhibition of GIRK channels has an antidepressant-like effect. |
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書誌情報 |
Neuroscience Letters 巻 481, 号 3, p. 188-190, 発行年 2010-09 |
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PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 20621160 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 10.1016/j.neulet.2010.07.003 | |||||
権利 | ||||||
権利情報 | © 2010 Elsevier Ireland | |||||
情報源(ISSN) | ||||||
関連名称 | 03043940 | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
形態 | ||||||
200911 bytes | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
日本十進分類法 | ||||||
主題 | 491.5 | |||||
出版者 | ||||||
出版者 | Elsevier | |||||
資源タイプ | ||||||
内容記述 | 論文(Article) | |||||
資源タイプ・ローカル | ||||||
雑誌掲載論文 | ||||||
資源タイプ・NII | ||||||
Journal Article | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
01 | ||||||
URL | ||||||
内容記述 | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T0G-50GWNCT-2&_user=4545557&_coverDate=09%2F13%2F2010&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000008298&_version=1&_urlVersion=0&_userid=4545557&md5=cafaf36c8982e86ec114e03bb455f157&searchtype=a |