WEKO3
アイテム
{"_buckets": {"deposit": "736616a1-7bc8-4adf-87fc-ef296db4c3e4"}, "_deposit": {"created_by": 1, "id": "24713", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "24713"}, "status": "published"}, "_oai": {"id": "oai:kumadai.repo.nii.ac.jp:00024713", "sets": ["416"]}, "author_link": ["110728", "110714", "107925", "110730", "110685", "110726", "110731", "119256", "110712", "110727", "110729", "110725", "110683", "110687", "125184"], "item_16_biblio_info_6": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2011-01-25", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "1-3", "bibliographicPageEnd": "108", "bibliographicPageStart": "106", "bibliographicVolumeNumber": "651", "bibliographic_titles": [{"bibliographic_title": "European Journal of Pharmacology"}]}]}, "item_16_creator_3": {"attribute_name": "別言語の著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "川浦, 一晃"}], "nameIdentifiers": [{"nameIdentifier": "110725", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "三木, 理沙"}], "nameIdentifiers": [{"nameIdentifier": "110726", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "浦嶋, 優里"}], "nameIdentifiers": [{"nameIdentifier": "110727", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "本田, 宗吉"}], "nameIdentifiers": [{"nameIdentifier": "110728", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "副田, 二三夫"}], "nameIdentifiers": [{"nameIdentifier": "110729", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "白崎, 哲哉"}], "nameIdentifiers": [{"nameIdentifier": "110730", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "高濱, 和夫"}], "nameIdentifiers": [{"nameIdentifier": "110731", "nameIdentifierScheme": "WEKO"}]}]}, "item_16_description_17": {"attribute_name": "フォーマット", "attribute_value_mlt": [{"subitem_description": "application/pdf", "subitem_description_type": "Other"}, {"subitem_description": "application/pdf", "subitem_description_type": "Other"}]}, "item_16_description_46": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"subitem_description": "論文(Article)", "subitem_description_type": "Other"}]}, "item_16_description_5": {"attribute_name": "内容記述", "attribute_value_mlt": [{"subitem_description": "Several antidepressants have been used to treat severe pain in clinics. Recently, we\nreported that the centrally acting non-narcotic antitussive (cough suppressant drug),\ntipepidine produces an antidepressant-like effect in the forced swimming test, although\nthe mechanism of action appears to be quite different from that of known\nantidepressants. In the present study, we investigated whether a combination of\ntipepidine and carbamazepine acts synergistically to induce an antinociceptive effect in\nthe acetic acid-induced writhing test in mice. Prior to studying the combination of\ntipepidine and carbamazepine, the analgesic action of tipepidine alone was also\nexamined in mice. Tipepidine at 5–40 mg/kg i.p. significantly reduced the number of\nwrithes induced by acetic acid in mice. Carbamazepine at 20 mg/kg i.p. also\nsignificantly reduced the writhing reaction. Furthermore, co-administration of\ncarbamazepine (5 and 10 mg/kg, i.p.) and tipepidine (2.5 mg/kg i.p.) significantly\ndecreased the number of writhes induced by acetic acid. This finding suggests that a\ncombination of carbamazepine and tipepidine may be a new strategy for the treatment\nof neuropathic pain such as what occurs in trigeminal neuralgia, because the use of\ncarbamazepine is often limited by its adverse effects and by reduction of its analgesic\nefficacy by microsomal enzyme induction.", "subitem_description_type": "Other"}]}, "item_16_description_77": {"attribute_name": "URL", "attribute_value_mlt": [{"subitem_description": "http://www.sciencedirect.com/science?_ob=ArticleURL\u0026_udi=B6T1J-51JXFP1-S\u0026_user=4545557\u0026_coverDate=01%2F25%2F2011\u0026_rdoc=1\u0026_fmt=high\u0026_orig=gateway\u0026_origin=gateway\u0026_sort=d\u0026_docanchor=\u0026view=c\u0026_acct=C000008298\u0026_version=1\u0026_urlVersion=0\u0026_userid=4545557\u0026md5=8b9435572e26660fc145da2e40e62499\u0026searchtype=a", "subitem_description_type": "Other"}]}, "item_16_publisher_36": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Elsevier B.V."}]}, "item_16_relation_10": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "21114989", "subitem_relation_type_select": "PMID"}}]}, "item_16_relation_11": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type": "isVersionOf", "subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1016/j.ejphar.2010.10.086", "subitem_relation_type_select": "DOI"}}]}, "item_16_relation_16": {"attribute_name": "情報源(ISSN)", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "00142999"}]}]}, "item_16_rights_12": {"attribute_name": "権利", "attribute_value_mlt": [{"subitem_rights": "© 2010 Elsevier B.V."}]}, "item_16_subject_20": {"attribute_name": "日本十進分類法", "attribute_value_mlt": [{"subitem_subject": "491.5", "subitem_subject_scheme": "NDC"}]}, "item_16_text_18": {"attribute_name": "形態", "attribute_value_mlt": [{"subitem_text_value": "178791 bytes"}, {"subitem_text_value": "27713 bytes"}]}, "item_16_text_47": {"attribute_name": "資源タイプ・ローカル", "attribute_value_mlt": [{"subitem_text_value": "雑誌掲載論文"}]}, "item_16_text_48": {"attribute_name": "資源タイプ・NII", "attribute_value_mlt": [{"subitem_text_value": "Journal Article"}]}, "item_16_text_49": {"attribute_name": "資源タイプ・DCMI", "attribute_value_mlt": [{"subitem_text_value": "text"}]}, "item_16_text_50": {"attribute_name": "資源タイプ・ローカル表示コード", "attribute_value_mlt": [{"subitem_text_value": "01"}]}, "item_16_text_76": {"attribute_name": "URI", "attribute_value_mlt": [{"subitem_text_value": "http://hdl.handle.net/2298/18939"}]}, "item_16_version_type_19": {"attribute_name": "著者版フラグ", "attribute_value_mlt": [{"subitem_version_resource": "http://purl.org/coar/version/c_ab4af688f83e57aa", "subitem_version_type": "AM"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "川浦, 一晃", "creatorNameLang": "ja"}, {"creatorName": "カワウラ, カズアキ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Kawaura, Kazuaki", "creatorNameLang": "en"}], "familyNames": [{"familyName": "川浦", "familyNameLang": "ja"}, {"familyName": "カワウラ", "familyNameLang": "ja-Kana"}, {"familyName": "Kawaura", "familyNameLang": "en"}], "givenNames": [{"givenName": "一晃", "givenNameLang": "ja"}, {"givenName": "カズアキ", "givenNameLang": "ja-Kana"}, {"givenName": "Kazuaki", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "119256", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "三木, 理沙", "creatorNameLang": "ja"}, {"creatorName": "ミキ, リサ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Miki, Risa", "creatorNameLang": "en"}], "familyNames": [{"familyName": "三木", "familyNameLang": "ja"}, {"familyName": "ミキ", "familyNameLang": "ja-Kana"}, {"familyName": "Miki", "familyNameLang": "en"}], "givenNames": [{"givenName": "理沙", "givenNameLang": "ja"}, {"givenName": "リサ", "givenNameLang": "ja-Kana"}, {"givenName": "Risa", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "110683", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Urashima, Yuri"}], "nameIdentifiers": [{"nameIdentifier": "110712", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "本田, 宗吉", "creatorNameLang": "ja"}, {"creatorName": "ホンダ, ソウキチ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Honda, Sokichi", "creatorNameLang": "en"}], "familyNames": [{"familyName": "本田", "familyNameLang": "ja"}, {"familyName": "ホンダ", "familyNameLang": "ja-Kana"}, {"familyName": "Honda", "familyNameLang": "en"}], "givenNames": [{"givenName": "宗吉", "givenNameLang": "ja"}, {"givenName": "ソウキチ", "givenNameLang": "ja-Kana"}, {"givenName": "Sokichi", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "110685", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "M. Shehata, Ahmed"}], "nameIdentifiers": [{"nameIdentifier": "110714", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "副田, 二三夫", "creatorNameLang": "ja"}, {"creatorName": "ソエダ, フミオ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Soeda, Fumio", "creatorNameLang": "en"}], "familyNames": [{"familyName": "副田", "familyNameLang": "ja"}, {"familyName": "ソエダ", "familyNameLang": "ja-Kana"}, {"familyName": "Soeda", "familyNameLang": "en"}], "givenNames": [{"givenName": "二三夫", "givenNameLang": "ja"}, {"givenName": "フミオ", "givenNameLang": "ja-Kana"}, {"givenName": "Fumio", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "107925", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "白崎, 哲哉", "creatorNameLang": "ja"}, {"creatorName": "シラサキ, テツヤ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Shirasaki, Tetsuya", "creatorNameLang": "en"}], "familyNames": [{"familyName": "白崎", "familyNameLang": "ja"}, {"familyName": "シラサキ", "familyNameLang": "ja-Kana"}, {"familyName": "Shirasaki", "familyNameLang": "en"}], "givenNames": [{"givenName": "哲哉", "givenNameLang": "ja"}, {"givenName": "テツヤ", "givenNameLang": "ja-Kana"}, {"givenName": "Tetsuya", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "110687", "nameIdentifierScheme": "WEKO"}]}, {"creatorAffiliations": [{"affiliationNameIdentifiers": [{"affiliationNameIdentifier": "", "affiliationNameIdentifierScheme": "ISNI", "affiliationNameIdentifierURI": "http://www.isni.org/isni/"}], "affiliationNames": [{"affiliationName": "", "affiliationNameLang": "ja"}]}], "creatorNames": [{"creatorName": "高濱, 和夫", "creatorNameLang": "ja"}, {"creatorName": "タカハマ, カズオ", "creatorNameLang": "ja-Kana"}, {"creatorName": "Takahama, Kazuo", "creatorNameLang": "en"}], "familyNames": [{"familyName": "高濱", "familyNameLang": "ja"}, {"familyName": "タカハマ", "familyNameLang": "ja-Kana"}, {"familyName": "Takahama", "familyNameLang": "en"}], "givenNames": [{"givenName": "和夫", "givenNameLang": "ja"}, {"givenName": "カズオ", "givenNameLang": "ja-Kana"}, {"givenName": "Kazuo", "givenNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "125184", "nameIdentifierScheme": "WEKO"}]}]}, "item_files": {"attribute_name": "ファイル情報", "attribute_type": "file", "attribute_value_mlt": [{"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 0, "filename": "EJP_651_1-3_Fig1-3.pdf", "filesize": [{"value": "27.7 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 27700.0, "url": {"label": "EJP_651_1-3_Fig1-3.pdf", "url": "https://kumadai.repo.nii.ac.jp/record/24713/files/EJP_651_1-3_Fig1-3.pdf"}, "version_id": "a127e587-c913-433e-9e71-c7eff25dde0b"}, {"accessrole": "open_date", "date": [{"dateType": "Available", "dateValue": "2020-03-02"}], "displaytype": "detail", "download_preview_message": "", "file_order": 1, "filename": "EJP_651_1-3_106-108.pdf", "filesize": [{"value": "178.8 kB"}], "format": "application/pdf", "future_date_message": "", "is_thumbnail": false, "licensetype": "license_free", "mimetype": "application/pdf", "size": 178800.0, "url": {"label": "EJP_651_1-3_106-108.pdf", "url": "https://kumadai.repo.nii.ac.jp/record/24713/files/EJP_651_1-3_106-108.pdf"}, "version_id": "7068b3bb-6ad3-44f2-9d5a-b1176ba5ba26"}]}, "item_keyword": {"attribute_name": "キーワード", "attribute_value_mlt": [{"subitem_subject": "Antinociceptive-like action", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Antitussives; Carbamazepine", "subitem_subject_scheme": "Other"}, {"subitem_subject": "G-protein coupled inwardly rectifying potassium ion channels", "subitem_subject_scheme": "Other"}, {"subitem_subject": "Tipepidine", "subitem_subject_scheme": "Other"}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Tipepidine enhances the antinociceptive-like action of carbamazepine in the acetic acid writhing test", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Tipepidine enhances the antinociceptive-like action of carbamazepine in the acetic acid writhing test"}]}, "item_type_id": "16", "owner": "1", "path": ["416"], "permalink_uri": "http://hdl.handle.net/2298/18939", "pubdate": {"attribute_name": "公開日", "attribute_value": "2011-05-19"}, "publish_date": "2011-05-19", "publish_status": "0", "recid": "24713", "relation": {}, "relation_version_is_last": true, "title": ["Tipepidine enhances the antinociceptive-like action of carbamazepine in the acetic acid writhing test"], "weko_shared_id": -1}
Tipepidine enhances the antinociceptive-like action of carbamazepine in the acetic acid writhing test
http://hdl.handle.net/2298/18939
http://hdl.handle.net/2298/18939698f9e8d-5077-423a-b1f9-342a99875b22
名前 / ファイル | ライセンス | アクション |
---|---|---|
EJP_651_1-3_Fig1-3.pdf (27.7 kB)
|
|
|
EJP_651_1-3_106-108.pdf (178.8 kB)
|
|
Item type | 学術雑誌論文 / Journal Article(1) | |||||
---|---|---|---|---|---|---|
公開日 | 2011-05-19 | |||||
タイトル | ||||||
タイトル | Tipepidine enhances the antinociceptive-like action of carbamazepine in the acetic acid writhing test | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | Antinociceptive-like action, Antitussives; Carbamazepine, G-protein coupled inwardly rectifying potassium ion channels, Tipepidine | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
川浦, 一晃
× 川浦, 一晃× 三木, 理沙× Urashima, Yuri× 本田, 宗吉× M. Shehata, Ahmed× 副田, 二三夫× 白崎, 哲哉× 高濱, 和夫 |
|||||
別言語の著者 |
川浦, 一晃
× 川浦, 一晃× 三木, 理沙× 浦嶋, 優里× 本田, 宗吉× 副田, 二三夫× 白崎, 哲哉× 高濱, 和夫 |
|||||
内容記述 | ||||||
内容記述 | Several antidepressants have been used to treat severe pain in clinics. Recently, we reported that the centrally acting non-narcotic antitussive (cough suppressant drug), tipepidine produces an antidepressant-like effect in the forced swimming test, although the mechanism of action appears to be quite different from that of known antidepressants. In the present study, we investigated whether a combination of tipepidine and carbamazepine acts synergistically to induce an antinociceptive effect in the acetic acid-induced writhing test in mice. Prior to studying the combination of tipepidine and carbamazepine, the analgesic action of tipepidine alone was also examined in mice. Tipepidine at 5–40 mg/kg i.p. significantly reduced the number of writhes induced by acetic acid in mice. Carbamazepine at 20 mg/kg i.p. also significantly reduced the writhing reaction. Furthermore, co-administration of carbamazepine (5 and 10 mg/kg, i.p.) and tipepidine (2.5 mg/kg i.p.) significantly decreased the number of writhes induced by acetic acid. This finding suggests that a combination of carbamazepine and tipepidine may be a new strategy for the treatment of neuropathic pain such as what occurs in trigeminal neuralgia, because the use of carbamazepine is often limited by its adverse effects and by reduction of its analgesic efficacy by microsomal enzyme induction. |
|||||
書誌情報 |
European Journal of Pharmacology 巻 651, 号 1-3, p. 106-108, 発行年 2011-01-25 |
|||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 21114989 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 10.1016/j.ejphar.2010.10.086 | |||||
権利 | ||||||
権利情報 | © 2010 Elsevier B.V. | |||||
情報源(ISSN) | ||||||
関連名称 | 00142999 | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
形態 | ||||||
178791 bytes | ||||||
形態 | ||||||
27713 bytes | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
日本十進分類法 | ||||||
主題 | 491.5 | |||||
出版者 | ||||||
出版者 | Elsevier B.V. | |||||
資源タイプ | ||||||
内容記述 | 論文(Article) | |||||
資源タイプ・ローカル | ||||||
雑誌掲載論文 | ||||||
資源タイプ・NII | ||||||
Journal Article | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
01 | ||||||
URL | ||||||
内容記述 | http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T1J-51JXFP1-S&_user=4545557&_coverDate=01%2F25%2F2011&_rdoc=1&_fmt=high&_orig=gateway&_origin=gateway&_sort=d&_docanchor=&view=c&_acct=C000008298&_version=1&_urlVersion=0&_userid=4545557&md5=8b9435572e26660fc145da2e40e62499&searchtype=a |