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Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma
http://hdl.handle.net/2298/25331
http://hdl.handle.net/2298/2533120abf1a9-9ebd-4087-b8af-7f2208b743ab
名前 / ファイル | ライセンス | アクション |
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article file.pdf (2.6 MB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-08-02 | |||||
タイトル | ||||||
タイトル | Therapeutic approaches targeting midkine suppress tumor growth and lung metastasis in osteosarcoma | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | midkine, osteosarcoma, lung metastasis, cell proliferation, anti-midkine antibody | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
Sueyoshi, Takanao
× Sueyoshi, Takanao× Jono, Hirofumi× Shinriki, Satoru× Ota, Kazutoshi× Ota, Tomoko× Tasaki, Masayoshi× Atsuyama, Eri× Yakushiji, Toshitake× 植田, 光晴× Obayashi, Konen× Mizuta, Hiroshi× 安東, 由喜雄 |
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別言語の著者 |
末吉, 貴直
× 末吉, 貴直× 城野, 博史× 神力, 悟× 太田, 和俊× 太田, 智子× 田崎, 雅義× 厚山, 恵理× 薬師寺, 俊剛× 植田, 光晴× 大林, 光念× 水田, 博志× 安東, 由喜雄 |
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内容記述 | ||||||
内容記述 | Midkine (MK) plays important roles in tumorigenesis, however, the biological function of MK and whether MK can be a therapeutic target in osteosarcoma are unclear. Here, we found that osteosarcoma tissues showed high MK expression. MK knockdown by small interfering RNA significantly induced apoptosis in osteosarcoma cells, whereas recombinant MK increased cell proliferation. Inhibition of MK signaling by anti-MK monoclonal antibody (anti-MK mAb) suppressed growth of osteosarcoma cells both in vitro and in vivo. Moreover, inhibition of MK function significantly suppressed lung metastasis in xenograft transplantation model. Targeting MK by anti-MK mAb may have value in the treatment of osteosarcoma. | |||||
書誌情報 |
Cancer Letters 巻 316, 号 1, p. 23-30, 発行年 2012-03 |
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ISSN | ||||||
収録物識別子 | 03043835 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 22099874 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 10.1016/j.canlet.2011.10.013 | |||||
権利 | ||||||
権利情報 | © 2012 Elsevier Ireland Ltd | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
形態 | ||||||
2640853 bytes | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
日本十進分類法 | ||||||
主題 | 490 | |||||
出版者 | ||||||
出版者 | Elsevier Ireland Ltd | |||||
資源タイプ | ||||||
内容記述 | 論文(Article) | |||||
資源タイプ・ローカル | ||||||
雑誌掲載論文 | ||||||
資源タイプ・NII | ||||||
Journal Article | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
01 | ||||||
URL | ||||||
内容記述 | http://www.sciencedirect.com/science/article/pii/S0304383511006306 |