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Polypseudorotaxanes of Pegylated α-Cyclodextrin/Polyamidoamine Dendrimer Conjugate with Cyclodextrins as a Sustained Release System for DNA
http://hdl.handle.net/2298/26022
http://hdl.handle.net/2298/260224a258a55-6540-4a22-a0e2-9d7a68c734dc
名前 / ファイル | ライセンス | アクション |
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Bioorganic and Medicinal Chemistry2012.VOL20-4.pdf (640.5 kB)
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Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2012-12-11 | |||||
タイトル | ||||||
タイトル | Polypseudorotaxanes of Pegylated α-Cyclodextrin/Polyamidoamine Dendrimer Conjugate with Cyclodextrins as a Sustained Release System for DNA | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | cyclodextrin, polypseudorotaxane, dendrimer, DNA, sustained release | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
Motoyama, Keiichi
× Motoyama, Keiichi× Hayashida, Kayoko× Higashi, Taishi× Arima, Hidetoshi |
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別言語の著者 |
本山, 敬一
× 本山, 敬一× 林田, 佳代子× 東, 大志× 有馬, 英俊 |
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内容記述 | ||||||
内容記述 | Nonviral gene delivery suffers from a number of limitations including short transgene expression times and low transfection efficiency. In this study, we examined whether polypseudorotaxanes (PPRXs) of polyethylene glycol (PEG, molecular weight: 2,000)-grafted α-cyclodextrin (α-CyD)/ polyamidoamine dendrimer conjugate (PEG-α-CDE) with CyDs have the potential for the novel sustained release systems for plasmid DNA (pDNA). The PEG-α-CDE/pDNA complex formed PPRXs with α-CyD and γ-CyD solutions, but not with β-CyD solution. In the PEG-α-CDE/CyDs PPRX systems, 20.6 mol of α-CyD and 11.8 mol of γ-CyD were involved in the PPRXs formation with one PEG chain by α-CyD and γ-CyD, respectively, consistent with in the PEG-dendrimer/CyDs systems. PEG-α-CDE/pDNA/α-CyD PPRX and PEG-α-CDE/pDNA/γ-CyD PPRX formed hexagonal and tetragonal columnar channels in the crystalline phase, respectively. In addition, the CyDs PPRX provided the sustained release of pDNA from PEG-α-CDE complex with pDNA at least 72 h in vitro. The release of pDNA from CyDs PPRX retarded as the volume of dissolution medium decreased. Furthermore, the PEG-α-CDE/γ-CyD PPRX system showed sustained transfection efficiency after intramuscular injection to mice at least for 14 days. These results suggest that the PEG-α-CDE/CyD PPRX systems are useful for novel sustained DNA release systems. | |||||
書誌情報 |
Bioorganic and Medicinal Chemistry 巻 20, 号 4, p. 1425-1433, 発行年 2012-02-15 |
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ISSN | ||||||
収録物識別子 | 09680896 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 22277591 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 10.1016/j.bmc.2011.12.060 | |||||
権利 | ||||||
権利情報 | © 2012 Elsevier Limited | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
形態 | ||||||
640544 bytes | ||||||
著者版フラグ | ||||||
出版タイプ | AM | |||||
日本十進分類法 | ||||||
主題 | 491.7 | |||||
出版者 | ||||||
出版者 | Elsevier Limited | |||||
資源タイプ | ||||||
内容記述 | 論文(Article) | |||||
資源タイプ・ローカル | ||||||
雑誌掲載論文 | ||||||
資源タイプ・NII | ||||||
Journal Article | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
01 | ||||||
URL | ||||||
内容記述 | http://www.sciencedirect.com/science/article/pii/S0968089612000028 |