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Several distinct enzymes catalyze 20α-hydroxysteroid dehydrogenase activity in mouse liver and kidney
http://hdl.handle.net/2298/27242
http://hdl.handle.net/2298/2724268ca250d-f576-4797-97d4-8d0d62cd218c
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-03-11 | |||||
タイトル | ||||||
タイトル | Several distinct enzymes catalyze 20α-hydroxysteroid dehydrogenase activity in mouse liver and kidney | |||||
言語 | ||||||
言語 | eng | |||||
キーワード | ||||||
主題 | 20α-Hydroxysteroid dehydrogenase activity, Mouse liver, Mouse kidney, Cofactor requirement, Inhibitors, Activators | |||||
資源タイプ | ||||||
資源タイプ | journal article | |||||
著者 |
今村, 順茂
× 今村, 順茂× Ohtaguro, Misa× 島田, 秀昭 |
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別言語の著者 |
今村, 順茂
× 今村, 順茂× 大田黒, 弥紗× 島田, 秀昭 |
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内容記述 | ||||||
内容記述 | The effects of flavonoids and quinones on NADPH- and NADH-dependent 20α-hydroxysteroid dehydrogenase (20α-HSD) activities were examined in cytosolic fractions from the liver and kidney of mice. Judging from the data for the inhibition of NADPH- and NADH-dependent 20α-HSD activities by flavonoids and quinones, enzyme catalyzing renal NADPH-dependent 20α-HSD activity was found to be distinct from enzyme(s) catalyzing hepatic NADPH- and NADH-dependent 20α-HSD activities. Sulfobromophthalein (SBP) had little ability to inhibit hepatic NADPH-dependent 20α-HSD activity and bromophenol blue (BPB) exhibited a weak activation against the enzyme activity, whereas SBP and BPB were potent and moderate inhibitors, respectively, of hepatic NADH-dependent 20α-HSD activity. Thus, enzyme catalyzing hepatic NADPH-dependent 20α-HSD activity appeared to be distinct from enzyme catalyzing hepatic NADH-dependent 20α-HSD activity. The data for the pH profiles of hepatic NADPH- and NADH-dependent 20α-HSD activities also led us to the conclusion. Based on these results, we propose the possibility that several distinct enzymes catalyze NADPH- and NADH-dependent 20α-HSD activities in cytosolic fractions from the liver and kidney of mice. | |||||
書誌情報 |
Journal of Steroid Biochemistry & Molecular Biology 巻 107, 号 1-2, p. 120-126, 発行年 2007-10 |
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ISSN | ||||||
収録物識別子 | 09600760 | |||||
PubMed番号 | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 17629694 | |||||
DOI | ||||||
関連タイプ | isVersionOf | |||||
関連識別子 | 10.1016/j.jsbmb.2007.02.010 | |||||
権利 | ||||||
権利情報 | © 2007 Elsevier Limited | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
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内容記述 | application/pdf | |||||
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内容記述 | application/pdf | |||||
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内容記述 | application/pdf | |||||
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著者版フラグ | ||||||
出版タイプ | AM | |||||
日本十進分類法 | ||||||
主題 | 491 | |||||
出版者 | ||||||
出版者 | Elsevier Limited | |||||
資源タイプ | ||||||
内容記述 | 論文(Article) | |||||
資源タイプ・ローカル | ||||||
雑誌掲載論文 | ||||||
資源タイプ・NII | ||||||
Journal Article | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
01 | ||||||
URL | ||||||
内容記述 | http://www.sciencedirect.com/science/article/pii/S0960076007001549 |