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Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, open-label, triple-arm trial
http://hdl.handle.net/2298/35683
http://hdl.handle.net/2298/35683eec4e223-f7f9-408d-bf58-c4121e6735d2
名前 / ファイル | ライセンス | アクション |
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srep35690.pdf (689.7 kB)
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Item type | 一般雑誌記事 / Article(1) | |||||
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公開日 | 2016-11-14 | |||||
タイトル | ||||||
タイトル | Activation of heat shock response to treat obese subjects with type 2 diabetes: a prospective, frequency-escalating, randomized, open-label, triple-arm trial | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ | article | |||||
著者 |
Kondo, Tatsuya
× Kondo, Tatsuya× Goto, Rieko× Ono, Kaoru× Kitano, Sayaka× Ann Suico, Mary× Sato, Miki× Igata, Motoyuki× Kawashima, Jyunji× Motoshima, Hiroyuki× Matsumura, Takeshi× Kai, Hirofumi× 荒木, 栄一 |
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別言語の著者 |
近藤, 龍也
× 近藤, 龍也× 後藤, 理英子× 小野, 薫× 北野, さやか× 佐藤, 美希× 井形, 元維× 河島, 淳司× 本島, 寛之× 松村, 剛× 甲斐, 広文× 荒木, 栄一 |
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内容記述 | ||||||
内容記述 | Activation of heat shock response (HSR) improves accumulated visceral adiposity and metabolic abnormalities in type 2 diabetes. To identify the optimal intervention strategy of the activation of the HSR provided by mild electrical stimulation (MES) with heat shock (HS) in type 2 diabetes. This study was a prospective, frequency-escalating, randomized, open-label, triple-arm trial in Japan. A total of 60 obese type 2 diabetes patients were randomized into three groups receiving two, four, or seven treatments per week for 12 weeks. No adverse events were identified. MES + HS treatment (when all three groups were combined), significantly improved visceral adiposity, glycemic control, insulin resistance, systemic inflammation, renal function, hepatic steatosis and lipid profile compared to baseline. The reduction in HbA1c was significantly greater among those treated four times per week (−0.36%) or seven times per week (−0.65%) than among those treated two times per week (−0.10%). The relative HbA1c levels in seven times per week group was significantly decreased when adjusted by two times per week group (−0.55%. p = 0.001). This research provides the positive impact of MES + HS to treat obese patients with type 2 diabetes mellitus. |
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書誌情報 |
Scientific Reports p. 1-11, 発行日 2016-10-19 |
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DOI | ||||||
関連タイプ | isIdenticalTo | |||||
関連識別子 | 10.1038/srep35690 | |||||
権利 | ||||||
権利情報 | © 2016 Macmillan Publishers Limited, part of Springer Nature. | |||||
フォーマット | ||||||
内容記述 | application/pdf | |||||
形態 | ||||||
689706 bytes | ||||||
著者版フラグ | ||||||
出版タイプ | VoR | |||||
日本十進分類法 | ||||||
主題 | 493.123 | |||||
その他の言語のタイトル | ||||||
その他のタイトル | 肥満2型糖尿病患者に対する熱ショック応答経路活性化 : 前向き介入頻度別ランダム化3群試験 | |||||
タイトル(ヨミ) | ||||||
その他のタイトル | ヒマン 2ガタ トウニョウビョウ カンジャ ニ タイスル ネツ ショック オウトウ ケイロ カッセイカ : マエムキ カイニュウ ヒンド ベツ ランダム カ 3グン シケン | |||||
出版者 | ||||||
出版者 | Springer Nature | |||||
資源タイプ | ||||||
内容記述 | 論文 | |||||
資源タイプ・ローカル | ||||||
雑誌掲載論文 | ||||||
資源タイプ・NII | ||||||
Article | ||||||
資源タイプ・DCMI | ||||||
text | ||||||
資源タイプ・ローカル表示コード | ||||||
01 | ||||||
URL | ||||||
内容記述 | http://www.nature.com/articles/srep35690 |