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oai:kumadai.repo.nii.ac.jp:00023764 2023-09-14T07:16:31Z 413:443

Reduced prefrontal cortical gray matter volume in young adults exposed to harsh corporal punishment 友田, 明美 トモダ, アケミ Tomoda, Akemi 友田 トモダ Tomoda 明美 アケミ Akemi 鈴木, 華子 スズキ, ハナコ Suzuki, Hanako 鈴木 スズキ Suzuki 華子 ハナコ Hanako Rabi, Keren Sheu, Yi-Shin Polcari, Ann Teicher, Martin H. © 2009 Elsevier Inc. 493.9 Corporal punishment (CP) Harsh corporal punishment (HCP) Voxel-based morphometry (VBM) Gray matter volume (GMV) Medial prefrontal cortex (MPFC) Dorsolateral prefrontal cortex (DLPFC) Anterior cingulate gyrus (AC) MRPFC (medial rostral prefrontal cortex) application/pdf 論文(Article) Objective:Harsh corporal punishment (HCP) during childhood is a chronic, developmental stressor associated with depression, aggression and addictive behaviors. Exposure to traumatic stressors, such as sexual abuse, is associated with alteration in brain structure, but nothing is known about the potential neurobiological consequences of HCP. The aim of this study was to investigate whether HCP was associated with discernible alterations in gray matter volume (GMV) using voxel-based morphometry (VBM). Methods: 1455 young adults (18?25 years) were screened to identify 23 with exposure to HCP (minimum 3 years duration, 12 episodes per year, frequently involving objects) and 22 healthy controls. High-resolution T1-weighted MRI datasets were obtained using Siemens 3 T trio scanner. Results: GMV was reduced by 19.1% in the right medial frontal gyrus (medial prefrontal cortex; MPFC, BA10) (P=0.037, corrected cluster level), by 14.5% in the left medial frontal gyrus (dorsolateral prefrontal cortex; DLPFC, BA9) (P=0.015, uncorrected cluster level) and by 16.9% in the right anterior cingulate gyrus (BA24) (Pb0.001, uncorrected cluster level) of HCP subjects. There were significant correlations between GMV in these identified regions and performance IQ on the WAIS-III. Conclusions: Exposing children to harsh HCP may have detrimental effects on trajectories of brain development. However, it is also conceivable that differences in prefrontal cortical development may increase risk of exposure to HCP. Elsevier 2009-08 eng journal article AM http://hdl.handle.net/2298/15289 https://kumadai.repo.nii.ac.jp/records/23764 https://doi.org/10.1016/j.neuroimage.2009.03.005 10538119 NeuroImage 47 SUPPL. 2 T66 T71 https://kumadai.repo.nii.ac.jp/record/23764/files/Neuroimage_MS_CP_2009r.pdf application/pdf 226.3 kB 2020-03-02