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        <identifier>oai:kumadai.repo.nii.ac.jp:00024852</identifier>
        <datestamp>2026-02-25T01:48:29Z</datestamp>
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          <dc:title xml:lang="ja">脳梗塞慢性期高血圧患者におけるアゼルニジピンの脳血流に対する効果</dc:title>
          <dc:title xml:lang="ja-Kana">ノウコウソク マンセイキ コウケツアツ カンジャ ニ オケル アゼルニジピン ノ ノウ ケツリュウ ニ タイスル コウカ</dc:title>
          <dc:title xml:lang="en">Effect of Azelnidepine on cerebral blood flow in hypertensive patients with post ischemic stroke</dc:title>
          <jpcoar:creator>
            <jpcoar:creatorName xml:lang="ja">渡邉, 聖樹</jpcoar:creatorName>
            <jpcoar:creatorName xml:lang="ja-Kana">ワタナベ, マサキ</jpcoar:creatorName>
            <jpcoar:creatorName xml:lang="en">Watanabe, Masaki</jpcoar:creatorName>
          </jpcoar:creator>
          <jpcoar:subject subjectScheme="NDC">377.5</jpcoar:subject>
          <jpcoar:subject xml:lang="ja" subjectScheme="Other">脳卒中</jpcoar:subject>
          <jpcoar:subject xml:lang="ja" subjectScheme="Other">脳梗塞</jpcoar:subject>
          <jpcoar:subject xml:lang="ja" subjectScheme="Other">高血圧</jpcoar:subject>
          <jpcoar:subject xml:lang="en" subjectScheme="Other">CCB</jpcoar:subject>
          <jpcoar:subject xml:lang="ja-Kana" subjectScheme="Other">アゼルニジピン</jpcoar:subject>
          <jpcoar:subject xml:lang="en" subjectScheme="Other">SPECT</jpcoar:subject>
          <datacite:description xml:lang="ja" descriptionType="Other">長時間作用型のカルシウム拮抗剤であるアゼルニジピンは、その高い脂溶性と血管壁選択性から脳血流量(cerebral blood flow: CBF)増加作用が期待されている。本研究の目的は、脳梗塞慢性期高血圧患者におけるアゼルニジピンの安全性、有用性、CBFに対する効果について、I-IMP single photon emission computed tomography (SPECT)を用いて評価することである。</datacite:description>
          <datacite:description xml:lang="en" descriptionType="Other">Azelnidipine, a long-acting calcium-channel blocker, is highly lipid soluble and selective for the vascular wall, and is expected to have an increasing effect on cerebral blood flow (CBF). The aim of this study is to investigate its safety and efficacy in stroke patients in the chronic stage as far as CBF is concerned using N-isopropyl-p-I-iodo amphetamine (I-IMP) single photon emission computed tomography (SPECT).</datacite:description>
          <dc:publisher xml:lang="ja">熊本大学</dc:publisher>
          <datacite:date dateType="Issued">2010-02-17</datacite:date>
          <dc:language>jpn</dc:language>
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          <jpcoar:identifier identifierType="HDL">http://hdl.handle.net/2298/19878</jpcoar:identifier>
          <jpcoar:identifier identifierType="URI">https://kumadai.repo.nii.ac.jp/records/24852</jpcoar:identifier>
          <dcndl:dissertationNumber>乙第930号</dcndl:dissertationNumber>
          <dcndl:degreeName xml:lang="ja">博士（医学）</dcndl:degreeName>
          <dcndl:dateGranted>2010-02-17</dcndl:dateGranted>
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            <jpcoar:nameIdentifier nameIdentifierScheme="kakenhi">17401</jpcoar:nameIdentifier>
            <jpcoar:degreeGrantorName xml:lang="ja">熊本大学</jpcoar:degreeGrantorName>
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            <datacite:date dateType="Available">2020-03-02</datacite:date>
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