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Genetic background of resistance to cadmium-induced testicular toxicity in inbred Wistar-Imamichi rats 島田, 秀昭 Shimada, Hideaki シマダ, ヒデアキ 島田 Shimada シマダ 秀昭 Hideaki ヒデアキ 羽田, 伊織 橋口, 敬志 今村, 順茂 Imamura, Yorishige イマムラ, ヨリシゲ 今村 Imamura イマムラ 順茂 Yorishige ヨリシゲ 島田, 秀昭 Shimada, Hideaki シマダ, ヒデアキ 島田 Shimada シマダ 秀昭 Hideaki ヒデアキ Hata, Iori Hashiguchi, Takashi 今村, 順茂 Imamura, Yorishige イマムラ, ヨリシゲ 今村 Imamura イマムラ 順茂 Yorishige ヨリシゲ © 2011 Springer 490 Cadmium Testicular toxicity Susceptibility Strain difference Genetic analysis Inbred rat application/pdf application/pdf application/pdf application/pdf application/pdf 論文(Article) We have previously reported that inbred Wistar-Imamichi (WI) rats are highly resistant to cadmium (Cd)-induced testicular toxicity compared to inbred Fischer 344 (F344) rats. The present study was to elucidate the genetic background of resistance to Cd-induced testicular toxicity in WI rats. The genetic analysis of susceptibility to Cd-induced testicular toxicity was conducted, by using Cd-resistant WI and Cd-sensitive F344 strains as the parental rats, and by using the testicular hemoglobin level as the indicator. In the frequency distribution of testicular hemoglobin levels in parental, first filial (F1) and second filial (F2) rats treated with Cd at a dose of 2.0 mg/kg, F1 rats had testicular hemoglobin levels intermediate to WI and F344 rats, and F2 rats segregated into three groups of low, intermediate and high phenotypes at the expected ratio. Furthermore, the backcross progeny between WI and F1 or between F344 and F1 segregated into two groups with the expected ratio. Based on a simple Mendelian genetic analysis, these segregation patterns lead us to conclude that two co-dominant alleles at a gene locus are responsible for the susceptibility to Cd-induced testicular toxicity in rats. This is the first report for the genetic analysis of susceptibility to Cd-induced testicular toxicity in inbred rat strains. http://www.springerlink.com/content/p412h850t3pw0v55/?MUD=MP Springer 2011-10 jpn journal article AM http://hdl.handle.net/2298/25965 https://kumadai.repo.nii.ac.jp/records/26341 10.1007/s00204-011-0662-9 0340-5761 Archives of Toxicology 85 10 1195 1199 https://kumadai.repo.nii.ac.jp/record/26341/files/Fig. 3.pdf application/pdf 29.9 kB 2020-03-02 https://kumadai.repo.nii.ac.jp/record/26341/files/Fig. 2.pdf application/pdf 11.2 kB 2020-03-02 https://kumadai.repo.nii.ac.jp/record/26341/files/Fig 1.pdf application/pdf 9.5 kB 2020-03-02 https://kumadai.repo.nii.ac.jp/record/26341/files/Table 1.pdf application/pdf 15.2 kB 2020-03-02 https://kumadai.repo.nii.ac.jp/record/26341/files/Text.pdf application/pdf 117.9 kB 2020-03-02