2026-03-08T03:31:42Z https://kumadai.repo.nii.ac.jp/oai

oai:kumadai.repo.nii.ac.jp:00021659 2026-01-30T01:57:22Z 343:347:354:355

非莢膜保有型インフルエンザ菌による TLR7 発現制御および肺炎球菌による炎症性メディエーターの発現制御に関する研究 : 細胞内シグナル伝達抑制因子としての脱ユビキチン化酵素 CYLD の関与 ヒキョウマク ホユウガタ インフルエンザキン ニヨル TLR7 ハツゲン セイギョ オヨビ ハイエンキュウキン ニヨル エンショウセイ メディエーター ノ ハツゲン セイギョ ニカンスル ケンキュウ : サイボウナイ シグナル デンタツ ヨクセイ インシ トシテノ ダツユビキチンカコウソ CYLD ノ カンヨ Analysis of the Signaling Mechanisms for the NTHi-induced TLR7 expression and the S. pneumoniae-induced inflammatory mediators : CYLD, a dual negative regulator of NTHi infection and S. pneumoniae infection 古賀, 友紹 コガ, トモアキ Koga, Tomoaki 377.5 NTHi TLR7 発現誘導 S. pneumoniae 熊本大学 博士（薬学） Infectious diseases such as pneumonia and tuberculosis that historically have killed millions of people were almost conquered in the middle of 20th century by the discovery of antibiotics, and development of chemotherapy. Despite these progresses, because of the inappropriate antibiotic use in the clinic, antibiotic-resistant strains of various bacteria have dramatically increased over the past decade. Moreover, the emergence of new pathogens and the resurgence of old ones have also increased. Therefore, development of alternative therapeutic strategies targeting host response is urgently needed for the treatment of various infections based on full understanding of the molecular pathogenesis of each infection. In the present study, I investigated the molecular mechanisms underlying nontypeable Haemophilus influenzae (NTHi) and Streptococcus pneumoniae (S. pneumoniae)-induced host defense responses. NTHi and S. pneumoniae are important human pathogens causing inflammatory diseases including otitis media, the exacerbation of chronic obstructive pulmonary disease (COPD), and pneumonia. thesis 熊本大学 2008-03-25 2008-03-25 VoR application/pdf 甲第152号 https://kumadai.repo.nii.ac.jp/record/21659/files/23-0152.pdf http://hdl.handle.net/2298/9378 https://kumadai.repo.nii.ac.jp/records/21659 jpn