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Nerve growth factor, interoception, and sympathetic neuron: Lesson from congenital insensitivity to pain with anhidrosis Indo, Yasuhiro 97413 Indo, Yasuhiro 93163 犬童, 康弘 インドウ, ヤスヒロ 493 Nerve growth factor (NGF) 神経成長因子 Receptor tyrosine kinase for NGF チロシンキナーゼ型神経成長因子受容体 TrkA protein TrkA タンパク質 NTRK1 gene NTRK1 遺伝子 TRKA gene TRKA 遺伝子 Congenital insensitivity to pain with anhidrosis 先天性無痛無汗症 Interoception 内感覚 Polymodal receptor ポリモーダル受容器 Sympathetic neuron 交感神経ニューロン Basal forebrain cholinergic neuron 前脳基底野コリン作動性ニューロン Emotion 情動 Pain 痛み 疼痛 Homeostasis 恒常性 Hereditary sensory and autonomic neuropathy type IV 遺伝性感覚自律神経性ニュー ロパシー IV 型 application/pdf 論文(Article) Nerve growth factor (NGF) is a well-known neurotrophic factor essential for the survival and maintenance of sensory and sympathetic neurons. Congenital insensitivity to pain with anhidrosis (CIPA) is a genetic disorder due to loss-of-function mutations in the NTRK1 (also known as TRKA) gene encoding TrkA, a receptor tyrosine kinase for NGF. Patients with CIPA provide us a rare opportunity to explore the developmental and physiological function of the NGF-dependent neurons in behavior, cognitive, and mental activities that are not available in animal studies. Here, I discuss the significance of findings that patients with CIPA lack NGF-dependent neurons, including interoceptive polymodal receptors, sympathetic postganglionic neurons, and probably several types of neurons in the brain. They also exhibit characteristic emotional behavior or problems. Together, the NGF-TrkA system is essential for the establishment of a neural network for interoception and homeostasis that may underlie 'gut feelings'. Thus, NGF-dependent neurons play a crucial role in emotional experiences and decision-making processes. Prospective studies focused on these neurons might provide further insights into the neural basis of human emotion and feeling. journal article Elsevier B.V. 2009-05 AM application/pdf Autonomic neuroscience: basic & clinical 1-2 147 3 8 AA11470577 https://kumadai.repo.nii.ac.jp/record/22407/files/AN-09YI.pdf http://hdl.handle.net/2298/11429 https://kumadai.repo.nii.ac.jp/records/22407 eng 15660702 Elsevier B.V.