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CDKインヒビターによるアポトーシス制御 CDK インヒビター ニ ヨル アポトーシス セイギョ Cyclin-dependent kinase inhibitors in the regulation of apoptosis 梶原, 隆太郎 カジハラ, リュウタロウ Kajihara, Ryutaro 福重, 翔太 フクシゲ, ショウタ Fukushige, Shota 田邊, 香野 タナベ, カノ Tanabe, Kano 乾, 誠治 イヌイ, セイジ Inui, Seiji 463.6 Cell cycle Cyclin Cyclin-depedent kinase p27 p21 Apoptosis Cell division relies on the activation of cyclins, which bind to cyclin-dependent kinases (CDKs) to induce cell cycle progression towards S phase and later to initiate mitosis. Since uncontrolled cyclin-dependent kinase activity is often the cause of human cancer, their function is tightly regulated by cell-cycle inhibitors such as the p21 and p27 Cip/Kip proteins. Following anti-mitogenic signals or DNA damage, p21 and p27 bind to cyclin-CDK complexes to inhibit their catalytic activity and induce cell-cycle arrest. Interestingly, recent discoveries suggest that p21 and p27 might have new activities that are unrelated to their function as CDK inhibitors. The identification of new targets of Cip/Kip proteins as well as evidence of Cip/Kip cytoplasmic relocalization have revealed unexpected functions of these proteins in the regulation of apoptosis. This article discusses recent insights into this possible additional functions of p21 and p27. departmental bulletin paper 熊本大学 2011-03-23 VoR application/pdf 熊本大学医学部保健学科紀要 7 1 9 1880-7151 AA12010572 https://kumadai.repo.nii.ac.jp/record/24891/files/MH0007_001-0009.pdf http://hdl.handle.net/2298/20118 https://kumadai.repo.nii.ac.jp/records/24891 jpn