| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-11-14 |
| タイトル |
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|
タイトル |
A monoacylglyceryltrimethylhomoserine, 21F121-A, containing a branched acyl group from Penicillium glaucoroseum |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Penicillium glaucoroseum, Monoacylglyceryltrimethylhomoserine, LCMS-guided purification, Structure determination |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
Ichiro, Kimura
Yuki, Hitora
Yusaku, Sadahiro
Teppei, Kawahara
塚本, 佐知子
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| 内容記述 |
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内容記述 |
A new monoacylglyceryltrimethylhomoserine, 21F121-A (1), was isolated from the culture of Penicillium glaucoroseum (21F00121) by LCMS-guided purification. The structure was elucidated by NMR and mass spectrometries. The absolute configuration of the homoserine moiety was analyzed by the ECD spectrum after acid hydrolysis, and the S-configuration of the glycerol moiety was determined based on the spectrum of the 1,2-dibenzoyl derivative after acid hydrolysis. Although a variety of diacylglyceryltrimethylhomoserine is distributed in lower plants and fungi, a limited number of studies on monoacyl derivatives have been reported. This is the fourth sample of monoacylglyceryltrimethylhomoserine discovered from a natural source, and the second sample isolated from a fungus. Compound 1 contains an unusual branched pentaene chain attached at the sn-1 position of glycerol and weakly inhibited the growth of HCT116 cells. |
| 書誌情報 |
en : Journal of Natural Medicines
巻 77,
p. 992-997,
発行年 2023-07-29
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| ISSN |
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収録物識別子 |
1340-3443 |
| DOI |
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関連タイプ |
isIdenticalTo |
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関連識別子 |
https://doi.org/10.1007/s11418-023-01735-5 |
| 権利 |
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|
権利情報 |
(C) 2023, The Author(s) under exclusive licence to The Japanese Society of Pharmacognosy |
| 著者版フラグ |
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出版タイプ |
VoR |
| 出版者 |
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出版者 |
Springer Nature |
|
言語 |
en |
s11418-023-01735-5.pdf (1 MB)
