| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-11-15 |
| タイトル |
|
|
タイトル |
Cyclopsammocinamides A and B, Enantiomeric Cyclic Peptides of Cyclocinamide A, from the Marine Sponge Psammocinia sp. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
enantiomeric cyclic peptide, LC-MS-guided isolation, marine sponge, Psammocinia species |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Ahmed, H. H. El-Desoky
Yuki, Hitora
Keita, Onodera
Yuji, Ise
Fitje, Losung
Remy, E. P. Mangindaan
塚本, 佐知子
|
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
LC-MS and molecular networking analyses of the extract of the marine sponge Psammocinia sp. indicated the presence of two new compounds with multiple halogens. LC-MS-guided isolation yielded cyclic peptides, cyclopsammocinamides A (1) and B (2), in an enantiomeric relationship to cyclocinamide A (3). Planar structures of 1 and 2 were elucidated by NMR and mass spectroscopic analyses and the absolute configurations of the amino acid residues were determined using Marfey’s method with their acid hydrolysates. The sponge extract exhibited cytotoxicity and the bioassay-guided isolation afforded a dimeric dilactone macrolide, swinholide A, as the cytotoxic compound. |
| 書誌情報 |
en : Chemical and Pharmaceutical Bulletin
巻 70,
号 11,
p. 818-822,
発行年 2022-11-01
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| ISSN |
|
|
収録物識別子 |
0009-2363 |
| DOI |
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|
関連タイプ |
isIdenticalTo |
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|
関連識別子 |
https://doi.org/10.1248/cpb.c22-00523 |
| 権利 |
|
|
権利情報 |
(C)2022 The Pharmaceutical Society of Japan |
| 著者版フラグ |
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|
出版タイプ |
VoR |
|
出版タイプResource |
http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| 出版者 |
|
|
出版者 |
The Pharmaceutical Society of Japan |
70_c22-00523.pdf (2.3 MB)
