| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-11-16 |
| タイトル |
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タイトル |
Taichunins E-T, Isopimarane Diterpenes and a 20-nor-Isopimarane, from Aspergillus taichungensis (IBT 19404): Structures and Inhibitory Effects on RANKL-Induced Formation of Multinuclear Osteoclasts |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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資源タイプ |
journal article |
| 著者 |
Ahmed, H. H. El-Desoky
Natsumi, Inada
Yuka, Maeyama
Hikaru, Kato
Yuki, Hitora
Momona, Sebe
Mika, Nagaki
Aika, Kai
Keisuke, Eguchi
Tomoaki, Inazumi
Yukihiko, Sugimoto
Jens, C. Frisvad
Robert, M. Williams
塚本, 佐知子
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| 内容記述 |
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内容記述 |
Fifteen new isopimarane-type diterpenes, taichunins E–S (1–15), and a new 20-nor-isopimarane, taichunin T (16), together with four known compounds were isolated from Aspergillus taichungensis (IBT 19404). The structures of these new compounds were determined by NMR and mass spectroscopy, and their absolute configurations were analyzed by NOESY and TDDFT calculations of ECD spectra. Taichunins G, K, and N (3, 7, and 10) completely inhibited the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts in RAW264 cells at 5 μM, with 3 showing 92% inhibition at a concentration of 0.2 μM. |
| 書誌情報 |
en : Journal of Natural Products
巻 84,
号 9,
p. 2475-2485,
発行年 2021-09-24
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| ISSN |
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収録物識別子 |
0163-3864 |
| DOI |
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関連タイプ |
isVersionOf |
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関連識別子 |
https://doi.org/10.1021/acs.jnatprod.1c00486 |
| 権利 |
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権利情報 |
(C)2021 American Chemical Society and American Society of Pharmacognosy |
| 権利 |
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|
権利情報 |
This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in Journal of Natural Products, copyright (C)2021 American Chemical Society and American Society of Pharmacognosy after peer review. To access the final edited and published work see https://doi.org/10.1021/acs.jnatprod.1c00486 |
| 著者版フラグ |
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出版タイプ |
AM |
| 出版者 |
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出版者 |
American Chemical Society |
|
言語 |
en |
acs_jnatpro_d1c00486.pdf (5.3 MB)
