| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-11-16 |
| タイトル |
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タイトル |
Neopetrosidines A-D, pyridine alkaloids isolated from the marine sponge Neopetrosia chaliniformis and their cell cycle elongation activity |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
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主題 |
Cell cycle elongation activity, HeLa/Fucci2 cell, Marine sponge, Neopetrosia chaliniformis, Pyridine alkaloid |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yuki, Hitora
Rika, Maeda
Koyo, Honda
Yusaku, Sadahiro
Yuji, Ise
Esther, D. Angkouw
Remy, E. P. Mangindaan
塚本, 佐知子
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| 内容記述 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Natural products that inhibit cell cycle progression show promise as anticancer agents and chemical probes. In our research on biologically active natural products that affect cell cycle progression of HeLa/fluorescent ubiquitination-based cell cycle indicator (Fucci)2 cells, the extract of the marine sponge Neopetrosia chaliniformis was revealed to inhibit cell proliferation. Purification of the extract afforded four new pyridine alkaloids, neopetrosidines A-D (1-4). Their structures were elucidated by the interpretation of spectroscopic data and chemical degradation. Compounds 1-4 were found to inhibit cell proliferation of HeLa/Fucci2 cells, and time-lapse imaging showed that 1 exerts its effect by increasing the duration of the cell cycle. Furthermore, we show that 1 perturbs bioenergetics to exhibit a cytostatic effect by reducing the mitochondrial membrane potential. |
| 書誌情報 |
en : Bioorganic & Medicinal Chemistry
巻 50,
p. 116461,
発行年 2021-11-15
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| ISSN |
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収録物識別子 |
0960-894X |
| DOI |
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関連タイプ |
isVersionOf |
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関連識別子 |
https://doi.org/10.1016/j.bmc.2021.116461 |
| 権利 |
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権利情報 |
(C)2021 Elsevier Ltd. All rights reserved. |
| 権利 |
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|
権利情報 |
This manuscript version is made available under the CC-BY-NC-ND 4.0 License.http://creativecommons.org/licenses/by-nc-nd/4.0/. |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
j_bmc_2021_116461.pdf (785 KB)
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