| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-11-16 |
| タイトル |
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|
タイトル |
Amakusamine from a Psammocinia sp. Sponge: Isolation, Synthesis, and SAR Study on the Inhibition of RANKL-Induced Formation of Multinuclear Osteoclasts |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yuka, Maeyama
Yuta, Nakashima
Hikaru, Kato
Yuki, Hitora
Kazuhiko Maki
Natsumi, Inada
Shunya, Murakami
Tomoaki, Inazumi
Yuji, Ise
Yukihiko, Sugimoto
Hayato, Ishikawa
塚本, 佐知子
|
| 内容記述 |
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内容記述タイプ |
Abstract |
|
内容記述 |
A simple methylenedioxy dibromoindole alkaloid, amakusamine (1), was isolated from a marine sponge of the genus Psammocinia, and its structure was determined from spectroscopic data, time-dependent density-functional theory calculations, and synthesis. Compound 1 inhibited the receptor activator of nuclear factor-κB ligand (RANKL)-induced formation of multinuclear osteoclasts with an IC50 value of 10.5 μM in RAW264 cells. The structure-activity relationship of 1 was also investigated with synthetic derivatives. |
| 書誌情報 |
en : Journal of Natural Products
巻 84,
号 10,
p. 2738-2743,
発行年 2021-10-22
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| ISSN |
|
|
収録物識別子 |
0163-3864 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
関連識別子 |
https://doi.org/10.1021/acs.jnatprod.1c00758 |
| 権利 |
|
|
権利情報 |
(C)2021 American Chemical Society and American Society of Pharmacognosy |
| 権利 |
|
|
権利情報 |
This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in [Journal of Natural Products], copyright (C)2021 American Chemical Society and American Society of Pharmacognosy after peer review. To access the final edited and published work see https://doi.org/10.1021/acs.jnatprod.1c00758 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
acs_jnatprod_1c00758.pdf (747 KB)
