| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-11-20 |
| タイトル |
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|
タイトル |
Colletofragarone A2 and Colletoins A-C from a Fungus Colletotrichum sp. Decrease Mutant p53 Levels in Cells |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Yusaku, Sadahiro
Yuki, Hitora
塚本, 佐知子
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| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
p53 is frequently mutated in tumor cells. Mutant p53 (mut p53) accumulates in cells to promote cancer progression, invasion, and metastasis, and it is attracting attention as a target for cancer therapies. In this study, we used immunofluorescence staining of Saos-2 cells harboring doxycycline-inducible p53R175H [Saos-2 (p53R175H) cells] to search for compounds from natural sources that can target mut p53 and found an extract of Colletotrichum sp. (13S020) that was active. Bioassay-guided fractionation of the extract afforded a known polyketide, colletofragarone A2 (1), and three new analogues, colletoins A–C (2–4). The relative and absolute configurations of 1 were determined by the spectroscopic method and DFT calculation. Compounds 1 and 2 inhibited the growth of Saos-2 (p53R175H) cells and decreased mut p53 in the cells. |
| 書誌情報 |
en : Journal of Natural Products
巻 84,
号 12,
p. 3131-3137,
発行年 2021-12-24
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| ISSN |
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収録物識別子 |
0163-3864 |
| DOI |
|
|
関連タイプ |
isVersionOf |
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関連識別子 |
https://doi.org/10.1021/acs.jnatprod.1c00913 |
| 権利 |
|
|
権利情報 |
(C)2021 American Chemical Society and American Society of Pharmacognosy |
| 権利 |
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|
権利情報 |
This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in [Journal of Natural Products], copyright (C)2021 American Chemical Society and American Society of Pharmacognosy after peer review. To access the final edited and published work see https://doi.org/10.1021/acs.jnatprod.1c00913 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 出版者 |
|
|
出版者 |
American Chemical Society |
acs_jnatprod_1c00913.pdf (1.2 MB)
