| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-11-22 |
| タイトル |
|
|
タイトル |
Colletofragarone A2 Inhibits Cancer Cell Growth In Vivo and Leads to the Degradation and Aggregation of Mutant p53 |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Yusaku, Sadahiro
Yuki, Hitora
Ichiro, Kimura
Natsuko, Hitora-Imamura
Risako, Onodera
Keiichi, Motoyama
塚本, 佐知子
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Mutant p53 not only loses its original tumor suppressor function but also acquires new abilities regarding oncogenic progression. Therefore, the strategy of targeting mutant p53 has attracted attention for cancer therapy. We isolated colletofragarone A2 (CF) from the fungus Colletotrichum sp. (13S020), which decreases mutant p53 levels in cells, and herein examine its effect on mutant p53. CF showed more potent cytotoxic activities on cells with p53R175H structural mutants than those with different p53 statuses such as a DNA-contact mutant, wild-type, and null cells. CF markedly decreased tumor cell growth in vivo using a mouse xenograft model with HuCCT1 (p53R175H) cells. Cotreatment of SK-BR-3 (p53R175H) cells with CF and cycloheximide decreased mutant p53 levels by promoting p53 degradation. In the presence of MG-132, CF induced the accumulation of the aggregated mutant p53. These results suggest that CF inhibits the function of molecular chaperones such as HSP90. |
| 書誌情報 |
en : Chemical Research in Toxicology
巻 35,
号 9,
p. 1598-1603,
発行年 2022-09-19
|
| ISSN |
|
|
収録物識別子 |
0893-228X |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
関連識別子 |
https://doi.org/10.1021/acs.chemrestox.2c00202 |
| 権利 |
|
|
権利情報 |
(C)2022 American Chemical Society |
| 権利 |
|
|
権利情報 |
This document is the unedited Author’s version of a Submitted Work that was subsequently accepted for publication in [Chemical Research in Toxicology], copyright (C)2022 American Chemical Society after peer review. To access the final edited and published work see https://doi.org/10.1021/acs.chemrestox.2c00202 |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
acs_chemrestox_2c00202.pdf (3.5 MB)
