| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-11-22 |
| タイトル |
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|
タイトル |
Arteperoxides A-C, tris-normonoterpene-sesquiterpene conjugates with peroxide-bridges from Artemisia judaica exhibiting antiosteoclastogenic activity |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Ahmed, H. El-Desoky
Toshifumi, Asano
Yuka, Maeyama
Hikaru, Kato
Yuki, Hitora
Eishu, Goto
Shunsuke, Kotani
Makoto, Nakajima
塚本, 佐知子
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Antiosteoclastogenic-guided screening was conducted with 120 extracts of the medicinal plants collected in Egypt that led to the selection of Artemisia judaica L. (Asteraceae). Three undescribed davanone-related terpenoids, arteperoxides A–C, were isolated from the extract with two known derivatives, hydroxydavanone and davana acid. Structural analysis revealed that arteperoxides A–C were tris-normonoterpene–sesquiterpene conjugates with peroxide bridges. Although davanone derivatives with peroxides, such as a hydroperoxyl and peroxyhemiketal groups, have been isolated from Artemisia species, arteperoxides A–C are the first variations observed to contain peroxide bridges between two terpene-derived units. The absolute configurations of arteperoxides A and B were studied based on their spectroscopic data compared with those of the semisynthetic analogs that have ether linkages. The natural and synthetic compounds were tested for the antiosteoclastogenic activity, and arteperoxide C and hydroxydavanone were more potent than other compounds at 20 μM. |
| 書誌情報 |
en : Phytochemistry
巻 206,
p. 113548,
発行年 2023-02-01
|
| ISSN |
|
|
収録物識別子 |
0031-9422 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
関連識別子 |
https://doi.org/10.1016/j.phytochem.2022.113548 |
| 権利 |
|
|
権利情報 |
(C)2022 Elsevier |
| 著者版フラグ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
j_phytochem_2022_113548.pdf (4.5 MB)
