| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-11-24 |
| タイトル |
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|
タイトル |
Aaptocarbamates A-G, chlorinated terpene carbamates with antiosteoclastogenic activities from the marine sponge Aaptos sp. |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Marine sponge, Aaptos sp., Suberitidae, Chlorinated terpene carbamate, Antiosteoclastogenesis |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Ahmed, H. El-Desoky
Keisuke, Eguchi
Ippei, Kagiyama
Yuki, Hitora
Hikaru, Kato
Yuji, Ise
Fitje, Losung
Remy, E.P. Mangindaan
塚本, 佐知子
|
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Six undescribed chlorinated sesquiterpene carbamates, aaptocarbamates A–F, and a chlorinated tris-norsesquiterpene carbamate, aaptocarbamate G, were isolated from the marine sponge Aaptos sp. collected in Indonesia. Aaptocarbamates D–F and G possess tetrahydrofurans and a tetrahydrofuranone, respectively. The relative configurations of the tetrahydrofuran units were determined by the NOE correlations and DFT-based calculation of the 13C chemical shifts. This is the first time that chlorinated terpene carbamates have been reported from natural sources. Various aaptamine derivatives have been reported from the Aaptos sponges so far, the isolation of chlorinated terpene carbamates is very rare. Aaptocarbamates A, B, and D showed 60% inhibition of the RANKL-induced formation of multinucleated osteoclasts in RAW264 macrophages at 20 μM. |
| 書誌情報 |
en : Phytochemistry
巻 216,
p. 113872,
発行年 2023-12-01
|
| ISSN |
|
|
収録物識別子 |
0031-9422 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
関連識別子 |
https://doi.org/10.1016/j.phytochem.2023.113872 |
| 権利 |
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|
権利情報 |
(C)2023 Elsevier Ltd. All rights reserved. |
| 著者版フラグ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 出版者 |
|
|
出版者 |
Elsevier |
j_phytochem_2023_113872.pdf (3.1 MB)
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