| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2023-11-24 |
| タイトル |
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|
タイトル |
Akanthomins A-C, aphidicolin analogs from a fungus Akanthomyces sp., that inhibit cell cycle |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Akanthomyces sp., Cordycipitaceae, Fungus, Aphidicolin derivative, Cell cycle inhibitor |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| 著者 |
Koyo, Honda
Yuki, Hitora
塚本, 佐知子
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Natural products that inhibit cell cycle progression may have potential as anticancer agents. In this study, cell cycle inhibition of microbial culture extracts was screened by fluorescent images using HeLa/Fucci2 cells. The culture extract of a fungus, Akanthomyces sp., inhibited the cell cycle progression at the S/G2/M phases, and bioassay-guided fractionation of the extract afforded three previously undescribed aphidicolin derivatives, namely akanthomins A–C, and an undescribed chromone glycoside, specifically 9-hydroxyeugenetin 9-O-β-d-(4-O-methyl)glucopyranoside, in addition to aphidicolin. The chemical structures of these compounds were elucidated by spectroscopic analysis and chemical derivatization. Using a flow cytometer, akanthomin A and aphidicolin were found to inhibit cell cycle progression at the S phase. |
| 書誌情報 |
en : Phytochemistry
巻 216,
p. 113885,
発行年 2023-12-01
|
| ISSN |
|
|
収録物識別子 |
0031-9422 |
| DOI |
|
|
関連タイプ |
isVersionOf |
|
|
関連識別子 |
https://doi.org/10.1016/j.phytochem.2023.113885 |
| 権利 |
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|
権利情報 |
(C)2023 Elsevier Ltd. All rights reserved. |
| 著者版フラグ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 出版者 |
|
|
出版者 |
Elsevier |
j_phytochem_2023_113885.pdf (3.2 MB)
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