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Akanthomins A-C, aphidicolin analogs from a fungus Akanthomyces sp., that inhibit cell cycle
http://hdl.handle.net/2298/0002000067
http://hdl.handle.net/2298/000200006750efeb03-44ee-40b5-ae65-683ebc06881c
| 名前 / ファイル | ライセンス | アクション |
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j_phytochem_2023_113885.pdf (3.2 MB)
Download is available from 2025/12/2.
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||||
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| 公開日 | 2023-11-24 | |||||||||||||||
| タイトル | ||||||||||||||||
| タイトル | Akanthomins A-C, aphidicolin analogs from a fungus Akanthomyces sp., that inhibit cell cycle | |||||||||||||||
| 言語 | en | |||||||||||||||
| 言語 | ||||||||||||||||
| 言語 | eng | |||||||||||||||
| キーワード | ||||||||||||||||
| 主題 | Akanthomyces sp., Cordycipitaceae, Fungus, Aphidicolin derivative, Cell cycle inhibitor | |||||||||||||||
| 資源タイプ | ||||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||||
| 資源タイプ | journal article | |||||||||||||||
| 著者 |
Koyo, Honda
× Koyo, Honda
× Yuki, Hitora
× 塚本, 佐知子
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| 内容記述 | ||||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||||
| 内容記述 | Natural products that inhibit cell cycle progression may have potential as anticancer agents. In this study, cell cycle inhibition of microbial culture extracts was screened by fluorescent images using HeLa/Fucci2 cells. The culture extract of a fungus, Akanthomyces sp., inhibited the cell cycle progression at the S/G2/M phases, and bioassay-guided fractionation of the extract afforded three previously undescribed aphidicolin derivatives, namely akanthomins A–C, and an undescribed chromone glycoside, specifically 9-hydroxyeugenetin 9-O-β-d-(4-O-methyl)glucopyranoside, in addition to aphidicolin. The chemical structures of these compounds were elucidated by spectroscopic analysis and chemical derivatization. Using a flow cytometer, akanthomin A and aphidicolin were found to inhibit cell cycle progression at the S phase. | |||||||||||||||
| 書誌情報 |
en : Phytochemistry 巻 216, p. 113885, 発行年 2023-12-01 |
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| ISSN | ||||||||||||||||
| 収録物識別子 | 0031-9422 | |||||||||||||||
| DOI | ||||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||||
| 関連識別子 | https://doi.org/10.1016/j.phytochem.2023.113885 | |||||||||||||||
| 権利 | ||||||||||||||||
| 権利情報 | (C)2023 Elsevier Ltd. All rights reserved. | |||||||||||||||
| 著者版フラグ | ||||||||||||||||
| 出版タイプ | AM | |||||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||||
| 出版者 | ||||||||||||||||
| 出版者 | Elsevier | |||||||||||||||
