{"created":"2024-09-27T05:45:47.341512+00:00","id":2000637,"links":{},"metadata":{"_buckets":{"deposit":"776f94be-adb1-4e23-856f-92cfad9b717f"},"_deposit":{"created_by":12,"id":"2000637","owner":"12","owners":[12],"pid":{"revision_id":0,"type":"depid","value":"2000637"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:02000637","sets":["415:416"]},"author_link":[],"control_number":"2000637","item_16_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2018-05-10","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"24","bibliographicPageStart":"23","bibliographicVolumeNumber":"277","bibliographic_titles":[{"bibliographic_title":"Journal of Controlled Release","bibliographic_titleLang":"en"}]}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Human serum albumin (HSA) is a superior carrier for delivering extracellular drugs. However, the development of a cell-penetrating HSA remains a great challenge due to its low membrane permeability. We report herein on the design of a series of palmitoyl-poly-arginine peptides (CPPs) and an evaluation of their cell-penetrating effects after forming a complex with HSA for use in intracellular drug delivery. The palmitoyl CPPs forms a stable complex with HSA by anchoring itself to the high affinity palmitate binding sites of HSA. Among the CPPs evaluated, a cyclic polypeptide composed of D-dodecaarginines, palmitoyl-cyclic-(D-Arg)12 was the most effective for facilitating the cellular uptake of HSA by HeLa cells. Such a superior cell-penetrating capability is primarily mediated by macropinocytosis. The effect of the CPP on pharmacological activity was examined using three drugs loaded in HSA via three different methods: a) an HSA-paclitaxel complex, b) an HSA-doxorubicin covalent conjugate and c) an HSA-thioredoxin fusion protein. The results showed that cell-penetrating efficiency was increased with a corresponding and significant enhancement in pharmacological activity. In conclusion, palmitoyl-cyclic-(D-Arg)12/HSA is a versatile cell-penetrating drug delivery system with great potential for use as a nano-carrier for a wide diversity of pharmaceutical applications.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_16_relation_61":{"attribute_name":"関連","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jconrel.2018.02.037","subitem_relation_type_select":"DOI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2018 Elsevier B.V. All rights reserved.","subitem_rights_language":"en"},{"subitem_rights":"This manuscript version is made available under the CC-BY-NC-ND 4.0 license. https://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_16_source_id_7":{"attribute_name":"item_16_source_id_7","attribute_value_mlt":[{"subitem_source_identifier":"0168-3659","subitem_source_identifier_type":"PISSN"}]},"item_16_version_type_19":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ichimizu, Shota","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Watanabe, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Maeda, Hitoshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Hamasaki, Keisuke","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nakamura, Yuka","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Chuang, Victor Tuan Giam","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kinoshita, Ryo","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Nishida, Kento","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Tanaka, Ryota","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Enoki, Yuki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Ishima, Yu","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kuniyasu, Akihiko","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Kobashigawa, Yoshihiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Morioka, Hiroshi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Futaki, Shiro","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Otagiri, Masaki","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Maruyama, Toru","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-09-27"}],"filename":"10.1016_j.jconrel.2018.02.037.pdf","filesize":[{"value":"1.3 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"url":"https://kumadai.repo.nii.ac.jp/record/2000637/files/10.1016_j.jconrel.2018.02.037.pdf"},"version_id":"bed282f1-70e2-42ea-bd76-76181a2dcd91"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Human serum albumin","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Cell-penetrating peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Macropinocytosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Drug binding","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Albumin fusion technology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Palmitate high affinity binding site","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Design and tuning of a cell-penetrating albumin derivative as a versatile nanovehicle for intracellular drug delivery","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Design and tuning of a cell-penetrating albumin derivative as a versatile nanovehicle for intracellular drug delivery","subitem_title_language":"en"}]},"item_type_id":"16","owner":"12","path":["416"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2024-09-27"},"publish_date":"2024-09-27","publish_status":"0","recid":"2000637","relation_version_is_last":true,"title":["Design and tuning of a cell-penetrating albumin derivative as a versatile nanovehicle for intracellular drug delivery"],"weko_creator_id":"12","weko_shared_id":-1},"updated":"2024-09-27T05:57:02.855476+00:00"}