| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-10-08 |
| タイトル |
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|
タイトル |
Cell attachment defines sensitivity to cold stress via the Hippo pathway |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
主題 |
Cold stress, Ferroptosis, Hippo pathway |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| 著者 |
Hao, Li
Yohei, Kanamori
Toshiro, Moroishi
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| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Although cells are frequently maintained at cold temperatures during experiments, the effects of cold stress on cell viability and subsequent cellular conditions remain elusive. In this study, we investigated the effects of cold stress on cancer cells under various culture conditions. We showed that cold stress induces ferroptosis, a form of cell death characterized by lipid peroxidation, in sensitive cancer cell lines. High cell density and serum starvation activate the Hippo pathway and suppress cold-induced cell death. Genetic deletion of Hippo pathway components enhances cold stress susceptibility. Furthermore, the cell attachment status influences the response to cold stress, with suspended cells showing greater resistance and faster recovery than attached cells. This study highlights the importance of cellular conditions and the Hippo pathway in the handling and storage of cancer cells at cold temperatures, thereby offering insights into experimental and clinical contexts. |
| bibliographic_information |
en : Biochemical and Biophysical Research Communications
巻 730,
p. 150373,
発行年 2024-10-20
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| item_16_source_id_7 |
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収録物識別子 |
0006-291X |
| item_16_relation_11 |
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関連タイプ |
isVersionOf |
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関連識別子 |
https://doi.org/10.1016/j.bbrc.2024.150373 |
| 権利 |
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|
権利情報 |
(C) 2024 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies. |
| 権利 |
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|
権利情報 |
This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 出版者 |
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出版者 |
Elsevier |
10.1016_j.bbrc.2024.150373.pdf (1.9 MB)
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