| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-10-17 |
| タイトル |
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|
タイトル |
Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Prostanoid, Mast cell, Irritant contact dermatitis, Helper T cell, Multiple sclerosis |
| 資源タイプ |
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|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Kohichi, Kawahara
Hirofumi, Hohjoh
Tomoaki, Inazumi
Soken, Tsuchiya
Yukihiko, Sugimoto
|
| 内容記述 |
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|
内容記述タイプ |
Abstract |
|
内容記述 |
Prostaglandin E2 (PGE2) is one of the most typical lipid mediators produced from arachidonic acid (AA) by cyclooxygenase (COX) as the rate-limiting enzyme, and acts on four kinds of receptor subtypes (EP1–EP4) to elicit its diverse actions including pyrexia, pain sensation, and inflammation. Recently, the molecular mechanisms underlying the PGE2 actions mediated by each EP subtype have been elucidated by studies using mice deficient in each EP subtype as well as several compounds highly selective to each EP subtype, and their findings now enable us to discuss how PGE2 initiates and exacerbates inflammation at the molecular level. Here, we review the recent advances in PGE2 receptor research by focusing on the activation of mast cells via the EP3 receptor and the control of helper T cells via the EP2/4 receptor, which are the molecular mechanisms involved in PGE2-induced inflammation that had been unknown for many years. We also discuss the roles of PGE2 in acute inflammation and inflammatory disorders, and the usefulness of anti-inflammatory therapies that target EP receptors. This article is part of a Special Issue entitled “Oxygenated metabolism of PUFA: analysis and biological relevance”. |
| bibliographic_information |
en : Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
巻 1851,
号 4,
p. 414-421,
発行年 2015-04
|
| item_16_source_id_7 |
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収録物識別子 |
1388-1981 |
| item_16_relation_11 |
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関連タイプ |
isVersionOf |
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関連識別子 |
https://doi.org/10.1016/j.bbalip.2014.07.008 |
| 権利 |
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|
権利情報 |
(C) 2014 Elsevier B.V. All rights reserved. |
| 権利 |
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|
権利情報 |
This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 出版タイプ |
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|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 出版者 |
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|
出版者 |
Elsevier |
10.1016_j.bbalip.2014.07.008.pdf (1.3 MB)
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