| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2024-10-17 |
| タイトル |
|
|
タイトル |
Prostanoid receptors and acute inflammation in skin |
|
言語 |
en |
| 言語 |
|
|
言語 |
eng |
| キーワード |
|
|
主題 |
Eicosanoids, Rodent, Signal transduction, Skin, Mast cell |
| 資源タイプ |
|
|
資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
|
資源タイプ |
journal article |
| アクセス権 |
|
|
アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Hirofumi, Hohjoh
Tomoaki, Inazumi
Soken, Tsuchiya
Yukihiko, Sugimoto
|
| 内容記述 |
|
|
内容記述タイプ |
Abstract |
|
内容記述 |
Prostanoids such as prostaglandins (PGs) and thromboxanes exert a wide variety of actions via nine types of G protein-coupled receptors, including four PGE2 receptors (EPs) and two PGD2 receptors (DPs). Recent studies have revealed that prostanoids trigger or modulate acute inflammation in the skin via multiple mechanisms involving distinct receptors and molecules; PGE2 elicits vascular permeability and edema formation via EP3 receptor on mast cells, and PGE2 increases blood flow by eliciting vasodilatation via EP2/EP4 receptors on smooth muscle cells. PGD2-DP1 signaling plays a role in mast cell maturation and mast cell-mediated inflammation. Therefore, the local inhibition of specific prostanoid receptor signaling is expected to be an effective strategy for the prevention and treatment of acute inflammation. |
| bibliographic_information |
en : Biochimie
巻 107,
号 A,
p. 78-81,
発行年 2014-12
|
| item_16_source_id_7 |
|
|
収録物識別子 |
0300-9084 |
| item_16_relation_11 |
|
|
関連タイプ |
isVersionOf |
|
|
関連識別子 |
https://doi.org/10.1016/j.biochi.2014.08.010 |
| 権利 |
|
|
権利情報 |
(C) 2014 Elsevier B.V. and Société française de biochimie et biologie Moléculaire (SFBBM). All rights reserved. |
| 権利 |
|
|
権利情報 |
This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/ |
| 出版タイプ |
|
|
出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 出版者 |
|
|
出版者 |
Elsevier |
10.1016_j.biochi.2014.08.010.pdf (1.9 MB)
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