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Human kidney organoids: progress and remaining challenges
http://hdl.handle.net/2298/0002000773
http://hdl.handle.net/2298/00020007733f440f88-6db4-4361-a7b7-a3cc5ead976d
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
10.1038_s41581-019-0176-x.pdf (389.9 KB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||
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| 公開日 | 2025-01-09 | |||||||
| タイトル | ||||||||
| タイトル | Human kidney organoids: progress and remaining challenges | |||||||
| 言語 | en | |||||||
| 言語 | ||||||||
| 言語 | eng | |||||||
| 資源タイプ | ||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||
| 資源タイプ | journal article | |||||||
| アクセス権 | ||||||||
| アクセス権 | open access | |||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||
| 著者 |
Ryuichi, Nishinakamura
× Ryuichi, Nishinakamura
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| 内容記述 | ||||||||
| 内容記述タイプ | Abstract | |||||||
| 内容記述 | Kidney organoids are regarded as important tools with which to study the development of the normal and diseased human kidney. Since the first reports of human pluripotent stem cell-derived kidney organoids 5 years ago, kidney organoids have been successfully used to model glomerular and tubular diseases. In parallel, advances in single-cell RNA sequencing have led to identification of a variety of cell types in the organoids, and have shown these to be similar to, but more immature than, human kidney cells in vivo. Protocols for the in vitro expansion of stem cell-derived nephron progenitor cells (NPCs), as well as those for the selective induction of specific lineages, especially glomerular podocytes, have also been reported. Although most current organoids are based on the induction of NPCs, an induction protocol for ureteric buds (collecting duct precursors) has also been developed, and approaches to generate more complex kidney structures may soon be possible. Maturation of organoids is a major challenge, and more detailed analysis of the developing kidney at a single cell level is needed. Eventually, organotypic kidney structures equipped with nephrons, collecting ducts, ureters, stroma and vascular flow are required to generate transplantable kidneys; such attempts are in progress. | |||||||
| bibliographic_information |
en : Nature Reviews Nephrology 巻 15, 号 10, p. 613-624, 発行年 2019-10 |
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| 収録物識別子 | 1759-5061 | |||||||
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| 関連タイプ | isVersionOf | |||||||
| 関連識別子 | https://doi.org/10.1038/s41581-019-0176-x | |||||||
| 権利 | ||||||||
| 権利情報 | (C) 2019, Springer Nature Limited | |||||||
| 権利 | ||||||||
| 権利情報 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1038/s41581-019-0176-x | |||||||
| 出版タイプ | ||||||||
| 出版タイプ | AM | |||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||
| 出版者 | ||||||||
| 出版者 | Springer Nature | |||||||
