| Item type |
学術雑誌論文 / Journal Article(1) |
| 公開日 |
2025-01-09 |
| タイトル |
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タイトル |
Induction of nephron progenitors and glomeruli from human pluripotent stem cells |
|
言語 |
en |
| 言語 |
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|
言語 |
eng |
| キーワード |
|
|
主題 |
Nephron progenitor, Six2, Sall1, Glomerulus, Podocyte, Nephrin |
| 資源タイプ |
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資源タイプ識別子 |
http://purl.org/coar/resource_type/c_6501 |
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資源タイプ |
journal article |
| アクセス権 |
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アクセス権 |
open access |
|
アクセス権URI |
http://purl.org/coar/access_right/c_abf2 |
| 著者 |
Ryuichi, Nishinakamura
Sazia, Sharmin
Atsuhiro, Taguchi
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| 内容記述 |
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内容記述タイプ |
Abstract |
|
内容記述 |
Studies of kidney regeneration using stem cells have progressed rapidly in recent years. Our group has developed a protocol to induce nephron progenitors from both mouse and human pluripotent stem cells which is based on a revised model of early stage kidney specification. The induced progenitors readily reconstitute three-dimensional nephron structures, including glomeruli and renal tubules, in vitro. We can further generate human induced pluripotent stem cells (iPSCs), in which nephrin-expressing glomerular podocytes are tagged with green fluorescent protein (GFP). The sorted GFP-positive cells retain the podocyte-specific molecular and structural features. Upon transplantation, mouse endothelial cells of the host animals are integrated into the human iPSC-derived glomeruli, and the podocytes show further maturation. Other laboratories have reported different protocols to induce nephron structures from human iPSCs in vitro. These findings will accelerate our understanding of kidney development and diseases in humans. |
| bibliographic_information |
en : Pediatric Nephrology
巻 32,
号 2,
p. 195-200,
発行年 2017-02
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| item_16_source_id_7 |
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収録物識別子 |
0931-041X |
| item_16_relation_11 |
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関連タイプ |
isVersionOf |
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関連識別子 |
https://doi.org/10.1007/s00467-016-3339-z |
| 権利 |
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権利情報 |
(C) 2016, IPNA |
| 権利 |
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権利情報 |
This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00467-016-3339-z |
| 出版タイプ |
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出版タイプ |
AM |
|
出版タイプResource |
http://purl.org/coar/version/c_ab4af688f83e57aa |
| 出版者 |
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出版者 |
Springer Nature |
10.1007_s00467-016-3339-z.pdf (254.1 KB)
10.1007_s00467-016-3339-z_Fig1.tiff (1.5 MB)
