WEKO3
アイテム
BMP signaling and its modifiers in kidney development
http://hdl.handle.net/2298/0002000776
http://hdl.handle.net/2298/0002000776f5e9dfa0-1782-4b05-bea2-7bddcf2559a3
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
10.1007_s00467-013-2671-9.pdf (180.7 KB)
|
|
| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2025-01-09 | |||||||||
| タイトル | ||||||||||
| タイトル | BMP signaling and its modifiers in kidney development | |||||||||
| 言語 | en | |||||||||
| 言語 | ||||||||||
| 言語 | eng | |||||||||
| キーワード | ||||||||||
| 主題 | Kidney development, Dullard, BMP, Metanephric mesenchyme | |||||||||
| 資源タイプ | ||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||
| 資源タイプ | journal article | |||||||||
| アクセス権 | ||||||||||
| アクセス権 | open access | |||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||
| 著者 |
Ryuichi, Nishinakamura
× Ryuichi, Nishinakamura
× Masaji, Sakaguchi
|
|||||||||
| 内容記述 | ||||||||||
| 内容記述タイプ | Abstract | |||||||||
| 内容記述 | The kidney develops through mutual interactions between the metanephric mesenchyme and the ureteric bud, the former of which contains nephron progenitors that give rise to glomeruli and renal tubules. Bone morphogenetic protein (BMP) signaling and its modifiers play important roles in many steps of kidney development. BMP4 inhibits ureteric bud attraction, and the BMP antagonist Gremlin is essential for the initial stage of ureteric budding. During mid-gestation, BMP7 maintains the nephron progenitors and, at the same time, sensitizes them to the ureteric bud-derived differentiation signal. Crossveinless2 is a pro-BMP factor, and its absence leads to kidney hypoplasia. After birth, when nephron progenitors have disappeared, Dullard, a phosphatase that inactivates BMP receptors, keeps BMP signaling at an appropriate level. Deletion of Dullard results in excessive BMP signaling and apoptosis of the postnatal nephrons. In this review I discuss the similarities and differences of BMP functions in kidney development, as well as in diseases. | |||||||||
| bibliographic_information |
en : Pediatric Nephrology 巻 29, 号 4, p. 681-686, 発行年 2014-04 |
|||||||||
| item_16_source_id_7 | ||||||||||
| 収録物識別子 | 0931-041X | |||||||||
| item_16_relation_11 | ||||||||||
| 関連タイプ | isVersionOf | |||||||||
| 関連識別子 | https://doi.org/10.1007/s00467-013-2671-9 | |||||||||
| 権利 | ||||||||||
| 権利情報 | (C) 2013, IPNA | |||||||||
| 権利 | ||||||||||
| 権利情報 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s00467-013-2671-9 | |||||||||
| 出版タイプ | ||||||||||
| 出版タイプ | AM | |||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||
| 出版者 | ||||||||||
| 出版者 | Springer Nature | |||||||||
