{"created":"2025-01-22T02:16:49.388678+00:00","id":2000816,"links":{},"metadata":{"_buckets":{"deposit":"4eb7692a-04c8-466f-9824-d202cc44a9a9"},"_deposit":{"created_by":90,"id":"2000816","owners":[90],"pid":{"revision_id":0,"type":"depid","value":"2000816"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:02000816","sets":["415:416"]},"author_link":[],"control_number":"2000816","item_16_biblio_info_6":{"attribute_name":"bibliographic_information","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-05-10","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"755","bibliographicPageStart":"744","bibliographicVolumeNumber":"321","bibliographic_titles":[{"bibliographic_title":"Journal of Controlled Release","bibliographic_titleLang":"en"}]}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Brain delivery of nanoparticles and macromolecular drugs depends on blood-brain barrier (BBB)-permeable carriers. In this study, we searched for cyclic heptapeptides facilitating BBB permeation of M13 phages by phage library screening using a transcellular permeability assay with hCMEC/D3 cell monolayers, a human BBB model. The M13 phage, which is larger than macromolecular drugs and nanoparticles, served as a model macromolecule. The screen identified cyclic heptapeptide SLSHSPQ (SLS) as a human BBB-permeable peptide. The SLS-displaying phage (SLS-phage) exhibited improved permeation across the cell monolayer of monkey and rat BBB co-culture models. The SLS-phage internalized into hCMEC/D3 cells via macropinocytosis and externalized via the exosome excretion pathway. SLS-phage distribution into brain parenchyma was observed in mice after intravenous administration. Moreover, liposome permeated across the BBB as cyclic SLS peptide conjugates. In conclusion, the cyclic SLS heptapeptide is a novel carrier candidate for brain delivery of macromolecular drugs and nanoparticles.","subitem_description_language":"en","subitem_description_type":"Abstract"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier","subitem_publisher_language":"en"}]},"item_16_relation_11":{"attribute_name":"item_16_relation_11","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.jconrel.2020.03.001","subitem_relation_type_select":"DOI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"(C) 2020 Elsevier B.V. All rights reserved.","subitem_rights_language":"en"},{"subitem_rights":"This manuscript version is made available under the CC-BY-NC-ND 4.0 license https://creativecommons.org/licenses/by-nc-nd/4.0/","subitem_rights_language":"en"}]},"item_16_source_id_7":{"attribute_name":"item_16_source_id_7","attribute_value_mlt":[{"subitem_source_identifier":"0168-3659","subitem_source_identifier_type":"PISSN"}]},"item_16_version_type_19":{"attribute_name":"出版タイプ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"open access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_abf2"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shunsuke, Yamaguchi","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Shingo, Ito","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Takeshi, Masuda","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Pierre-Olivier, Couraud","creatorNameLang":"en"}]},{"creatorNames":[{"creatorName":"Sumio, Ohtsuki","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2025-01-22"}],"filename":"10.1016_j.jconrel.2020.03.001.pdf","filesize":[{"value":"1.5 MB"}],"format":"application/pdf","licensetype":"license_5","mimetype":"application/pdf","url":{"url":"https://kumadai.repo.nii.ac.jp/record/2000816/files/10.1016_j.jconrel.2020.03.001.pdf"},"version_id":"d1ea9a28-3e96-4b90-b29b-c6474de41821"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Cyclic peptide","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Phage display technology","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Brain delivery","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"Macromolecule","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"item_resource_type","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Novel cyclic peptides facilitating transcellular blood-brain barrier transport of macromolecules in vitro and in vivo","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Novel cyclic peptides facilitating transcellular blood-brain barrier transport of macromolecules in vitro and in vivo","subitem_title_language":"en"}]},"item_type_id":"16","owner":"90","path":["416"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2025-01-22"},"publish_date":"2025-01-22","publish_status":"0","recid":"2000816","relation_version_is_last":true,"title":["Novel cyclic peptides facilitating transcellular blood-brain barrier transport of macromolecules in vitro and in vivo"],"weko_creator_id":"90","weko_shared_id":-1},"updated":"2025-01-23T04:22:35.191856+00:00"}