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Changes of Blood-Brain Barrier and Brain Parenchymal Protein Expression Levels of Mice under Different Insulin-Resistance Conditions Induced by High-Fat Diet
http://hdl.handle.net/2298/0002000818
http://hdl.handle.net/2298/000200081814dbc0a4-52a4-43e9-954b-d8115dc33673
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
10.1007_s11095-019-2674-8.pdf (1.3 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||||||||||
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| 公開日 | 2025-01-22 | |||||||||||||
| タイトル | ||||||||||||||
| タイトル | Changes of Blood-Brain Barrier and Brain Parenchymal Protein Expression Levels of Mice under Different Insulin-Resistance Conditions Induced by High-Fat Diet | |||||||||||||
| 言語 | en | |||||||||||||
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| 言語 | eng | |||||||||||||
| キーワード | ||||||||||||||
| 主題 | Blood-brain barrier, central nervous system, insulin resistance, quantitative proteomics, type II diabetes mellitus | |||||||||||||
| 資源タイプ | ||||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||||||||||
| 資源タイプ | journal article | |||||||||||||
| アクセス権 | ||||||||||||||
| アクセス権 | open access | |||||||||||||
| アクセス権URI | http://purl.org/coar/access_right/c_abf2 | |||||||||||||
| 著者 |
Seiryo, Ogata
× Seiryo, Ogata
× Shingo, Ito
× Takeshi, Masuda
× Sumio, Ohtsuki
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| 内容記述 | ||||||||||||||
| 内容記述タイプ | Abstract | |||||||||||||
| 内容記述 | Purpose The purpose of the present study was to investigate changes of blood-brain barrier (BBB) and brain parenchymal protein expression due to type II diabetes mellitus (T2DM) induced by a high-fat diet (HFD) by using SWATH-based quantitative proteomics. Methods Mice were fed a HFD for 2 or 10 weeks, and then SWATH-based quantitative proteomic analysis, western blot analysis, immunohistochemistry and functional transport studies were performed. Results In brain capillaries, expression levels of BBB transporters (Glut1, P-glycoprotein) and tight-junction proteins (claudin-5, occludin) were significantly reduced in HFD mice at 2 weeks, but recovered to the levels in the normal diet (ND) group at 10 weeks. P-glycoprotein function at the BBB was reduced at 2 weeks. In the cerebral cortex and hippocampus, neurofilament, which is important for neuronal function, was decreased in HFD mice at 2 weeks, but recovered at 10 weeks. Conclusion Our results suggest that changes in the status of insulin resistance influence expression of BBB transporters, which in turn may alter the expression of cognitive function-related proteins. |
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| bibliographic_information |
en : Pharmaceutical Research 巻 36, 号 10, p. 141, 発行年 2019-10 |
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| item_16_source_id_7 | ||||||||||||||
| 収録物識別子 | 0724-8741 | |||||||||||||
| item_16_relation_11 | ||||||||||||||
| 関連タイプ | isVersionOf | |||||||||||||
| 関連識別子 | https://doi.org/10.1007/s11095-019-2674-8 | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報 | (C) 2019, Springer Science Business Media, LLC, part of Springer Nature | |||||||||||||
| 権利 | ||||||||||||||
| 権利情報 | This version of the article has been accepted for publication, after peer review (when applicable) and is subject to Springer Nature’s AM terms of use, but is not the Version of Record and does not reflect post-acceptance improvements, or any corrections. The Version of Record is available online at: http://dx.doi.org/10.1007/s11095-019-2674-8 | |||||||||||||
| 出版タイプ | ||||||||||||||
| 出版タイプ | AM | |||||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||||||||||
| 出版者 | ||||||||||||||
| 出版者 | Springer Nature | |||||||||||||
