{"created":"2023-06-19T09:10:02.752022+00:00","id":21506,"links":{},"metadata":{"_buckets":{"deposit":"9fae8410-0698-4b2c-bb0d-cd6a15506893"},"_deposit":{"created_by":1,"id":"21506","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"21506"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00021506","sets":["343:347:348:349"]},"author_link":["92387"],"item_14_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Inhibition of DNA binding of transcriptional factor Sox2 by sumoylation"}]},"item_14_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"SUMO ホンヤク ゴ シュウショク ニ ヨル テンシャ インシ Sox2 ノ DNA ケツゴウ 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ubiquitin-related modifier (SUMO) は、被修飾タンパク質のリジン残基側鎖にイソペプチド結合する翻訳後修飾因子である。SUMOによるタンパク質修飾は酵母からヒトを含む高等生物まで保存されており、細胞核機能、転写制御への関わりが示唆されてきた。本論文では、Sox2の機能制御機構とSUMO修飾との関連を明らかにすることを目的とした。","subitem_description_type":"Other"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"2185360 bytes"},{"subitem_text_value":"31442 bytes"}]},"item_14_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"博士論文"}]},"item_14_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Thesis or 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