{"created":"2023-06-19T09:10:03.218112+00:00","id":21513,"links":{},"metadata":{"_buckets":{"deposit":"bdafadf8-b5ed-4ee5-9947-f20a1aad739e"},"_deposit":{"created_by":127,"id":"21513","owners":[127],"pid":{"revision_id":0,"type":"depid","value":"21513"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00021513","sets":["343:347:348:349"]},"author_link":[],"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03-27","bibliographicIssueDateType":"Issued"}}]},"item_14_date_granted_74":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2007-03-27"}]},"item_14_degree_grantor_72":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"熊本大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_14_degree_name_71":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"We demonstrated a dose-dependent increase in levels of active matrix metalloproteinase (MMP)-2 in the vitreous after plasmin injection. The time course of MMP-2 activity after plasmin administration showed that MMP-2 was significantly activated at 5 and 15 min after injection. Scanning electron microscopy demonstrated a smooth retinal surface in plasmin-teated eyes, suggesting the possibility that activation of endogenous MMP-2 by exogenous plasmin leads to induction of posterior vitreous detachment (PVD).  In addition, we revealed the effects of intravitreal injection of nattokinase for induction of PVD. Nattokinase is a serine protease produced by Bacillus subtilis (natto). This enzyme displays potent fibrinolytic activity, enhances plasminogen activators, and inactivates a plasminogen activator inhibitor. Under scanning electron microscopy, smooth retinal surfaces were seen at 30 min after injection with nattokinase in rabbit eyes, indicating the occurrence of PVD. We also confirmed the safety of this treatment by electroretinography and histological examination. The results suggest that nattokinase is a useful enzyme for pharmacologic vitreolysis because of its efficacy in inducing PVD．","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_14_dissertation_number_75":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1576号"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学","subitem_publisher_language":"ja"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲博医第1576号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"髙野, 晃臣","creatorNameLang":"ja"},{"creatorName":"タカノ, アキオミ","creatorNameLang":"ja-Kana"},{"creatorName":"Takano, Akiomi","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1576.pdf","filesize":[{"value":"3.8 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1576.pdf","url":"https://kumadai.repo.nii.ac.jp/record/21513/files/22-1576.pdf"},"version_id":"48a3c976-f6f5-4868-93b5-f143fd99637e"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"Mechanism of induction of posterior vitreous detachment by intravireal plasmin infection, and development of a novel enzyme for pharmacologic vitreolysis","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Mechanism of induction of posterior vitreous detachment by intravireal plasmin infection, and development of a novel enzyme for pharmacologic vitreolysis","subitem_title_language":"en"},{"subitem_title":"プラスミン併用硝子体手術における後部硝子体剥離誘導の機序の解明と酵素併用硝子体手術に用いる新規な酵素の開発","subitem_title_language":"ja"},{"subitem_title":"プラスミン ヘイヨウ ショウシタイ シュジュツ ニ オケル コウブ ショウタイ ハクリ ユウドウ ノ キジョ ノ カイメイ ト コウソ ヘイヨウ ショウシタイ シュジュツ ニ モチイル シンキナ コウソ ノ カイハツ","subitem_title_language":"ja-Kana"}]},"item_type_id":"14","owner":"127","path":["349"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-08-13"},"publish_date":"2014-08-13","publish_status":"0","recid":"21513","relation_version_is_last":true,"title":["Mechanism of induction of posterior vitreous detachment by intravireal plasmin infection, and development of a novel enzyme for pharmacologic vitreolysis"],"weko_creator_id":"127","weko_shared_id":-1},"updated":"2026-01-08T00:26:51.111723+00:00"}