WEKO3
アイテム
口腔扁平上皮癌の浸潤機構についての研究 : ADAM-17 による CD44 切断の関与と NF-κB 抑制因子の効果
http://hdl.handle.net/2298/8224
http://hdl.handle.net/2298/8224a86d2aee-0123-410f-915e-c23a32576373
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
22-1577.pdf (3.1 MB)
|
|
| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 公開日 | 2014-08-13 | |||||||||||
| タイトル | ||||||||||||
| タイトル | 口腔扁平上皮癌の浸潤機構についての研究 : ADAM-17 による CD44 切断の関与と NF-κB 抑制因子の効果 | |||||||||||
| 言語 | ja | |||||||||||
| タイトル | ||||||||||||
| タイトル | コウクウ ヘンペイ ジョウヒ ガン ノ シンジュン キコウ ニ ツイテ ノ ケンキュウ ADAM-17 ニ ヨル CD44 セツダン ノ カンヨ ト NF-κB ヨクセイ インシ ノ コウカ | |||||||||||
| 言語 | ja-Kana | |||||||||||
| タイトル | ||||||||||||
| タイトル | Molecular mechanism for the invasion of oral squamous cell carcinoma : the involvement of ADAM-17-mediated CD44 cleavage and the effect of NF-κB inhibitor | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | jpn | |||||||||||
| キーワード | ||||||||||||
| 主題 | 口腔扁平上皮癌 CD44, ADAM-17 |
|||||||||||
| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||||||||
| 資源タイプ | thesis | |||||||||||
| 著者 |
高宗, 康隆
× 高宗, 康隆
|
|||||||||||
| 内容記述 | ||||||||||||
| 内容記述 | ADAM-17 (a disintegrin and metalloproteinase 17) is a membrane-anchored protein, which can cleave the ectodomain in a variety of transmembrane proteins. In the vitro experiments with tumor cells, ADAM-17 is reported to cleave CD44, an adhesion molecule that interacts with hyaluronic acid, to promote tumor cell migration. In the present study, we examined ADAM-17 expression and CD44 cleavage in specimens from 50 patients diagnosed to have oral squamous cell carcinoma (SCC). Each specimen was divided into two pleces, one was studied by immunohistochemistry and the other was subjected to a Western blot. By coordinating the results of both analyses, ADAM-17 expression was evaluated to be high in 23 cases (46%). When CD44 cleavage was also studied by immunohistochemical staining as well as with Western blotting, CD44 cleavage was judged to be positive in 29 cases (58%). When the ADAM-17 expression level was compared with the CD44 cleavage state, most of the cases expressing high levels of ADAM-17 (87%) showed positive CD44 cleavage. The level of ADAM-17 expression was significantly correlated to the nodal metastasis and local recurrence in oral SCC. Our findings suggest that ADAM-17 is involved in CD44 cleavage and contributes to tumor progression in oral SCC. | |||||||||||
| 書誌情報 |
発行年 2007-03-27 |
|||||||||||
| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 日本十進分類法 | ||||||||||||
| 主題 | 377.5 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 熊本大学 | |||||||||||
| 言語 | ja | |||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士（医学）(ja) | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関名 | 熊本大学 | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2007-03-27 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第1577号 | |||||||||||
| 学位番号 | ||||||||||||
| 値 | 甲博医第1577号 | |||||||||||
