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新規ヒト癌関連抗原 Secreted protein acidic and rich in cysteine (SPARC) の癌の診断と治療における有用性
http://hdl.handle.net/2298/8248
http://hdl.handle.net/2298/82489f3a65fb-60ea-4f55-baa1-157bb6cf3a00
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
22-1579.pdf (4.7 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2014-08-12 | |||||
| タイトル | ||||||
| タイトル | 新規ヒト癌関連抗原 Secreted protein acidic and rich in cysteine (SPARC) の癌の診断と治療における有用性 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| キーワード | ||||||
| 主題 | 抗腫瘍免疫, 抗原, メラノーマ, 遺伝子 | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||
| 資源タイプ | thesis | |||||
| 著者 |
生田, 義明
× 生田, 義明 |
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| 別言語の著者 |
生田, 義明
× 生田, 義明 |
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| 内容記述 | ||||||
| 内容記述 | Purpose: To establish effective diagnostic method and anti-tumor immunotherapy for several cancers, we tried to identify a novel tumor-associated antigen. Experimental design: We analyzed data obtained from cDNA microarray analysis of diffuse gastric cancer tissue and 29 normal tissues to find a novel tumor-associated antigen, secreted protein acidic and rich in cysteine (SPARC). Because melanoma cells were reported to express a large amount of SPARC, and because SPARC is a secreted protein, at first, secreted SPARC protein was quantified using ELISA in the sera from 109 melanoma patients, 5 patients with large congenital melanocytic nevus, 61 age-matched healthy donors and 13 disease-free patients after undergoing a surgical removal. We also quantified two other known tumor markers for melanoma, GPC3 and 5-S-cysteinyldopa (5-S-CD), in the same serum samples, and compared these markers for their diagnostic value. Because of the similarities in the binding peptide motifs shared between H2-Kd and HLA-A24 (A*2402), 4 peptides having these motifs were synthesized. Then, we investigated whether the H2-Kd-restricted SPARC peptides could induce SPARC reactive cytotoxic T lymphocytes (CTLs) or not. In addition, we investigated the effect of the pre-immunization of BM-DC pulsed with the SPARC epitope peptides on a growth of SPARC-expressing tumor cells implanted in BALB/c mouse. |
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| 書誌情報 | 発行年 2007-03-27 | |||||
| フォーマット | ||||||
| 内容記述 | application/pdf, application/pdf, text/plain | |||||
| 形態 | ||||||
| 値 | 4720777 bytes, 60996 bytes, 102697 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | VoR | |||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||
| 日本十進分類法 | ||||||
| 主題 | 377.5 | |||||
| その他の言語のタイトル | ||||||
| その他のタイトル | Secreted protein acidic and rich in cysteine, an ideal cancer-associated antigen useful for serum diagnosis and immunotherapy of cancers, identified using cDNA microarray analysis | |||||
| タイトル（ヨミ） | ||||||
| その他のタイトル | シンキ ヒト ガン カンレン コウゲン Secreted protein acidic and rich in cysteine (SPARC) ノ ガン ノ シンダン ト チリョウ ニ オケル ユウヨウセイ | |||||
| 出版者 | ||||||
| 出版者 | 熊本大学 | |||||
| 資源タイプ | ||||||
| 内容記述 | 学位論文(Thesis) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 博士論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Thesis or Dissertation | |||||
| 資源タイプ・DCMI | ||||||
| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 03 | |||||
| 学位番号 | ||||||
| 値 | 甲博医第1579号 | |||||
