{"created":"2023-06-19T09:10:04.961934+00:00","id":21547,"links":{},"metadata":{"_buckets":{"deposit":"ca1d6f6b-d512-4932-84b4-e38872a9e11e"},"_deposit":{"created_by":127,"id":"21547","owners":[127],"pid":{"revision_id":0,"type":"depid","value":"21547"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00021547","sets":["343:347:348:349"]},"author_link":[],"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03-27","bibliographicIssueDateType":"Issued"}}]},"item_14_date_granted_74":{"attribute_name":"学位授与年月日","attribute_value_mlt":[{"subitem_dategranted":"2007-03-27"}]},"item_14_degree_grantor_72":{"attribute_name":"学位授与機関","attribute_value_mlt":[{"subitem_degreegrantor":[{"subitem_degreegrantor_language":"ja","subitem_degreegrantor_name":"熊本大学"}],"subitem_degreegrantor_identifier":[{"subitem_degreegrantor_identifier_name":"17401","subitem_degreegrantor_identifier_scheme":"kakenhi"}]}]},"item_14_degree_name_71":{"attribute_name":"学位名","attribute_value_mlt":[{"subitem_degreename":"博士（医学）","subitem_degreename_language":"ja"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Endothelial cells (ECs) in blood vessels adhere to each other through specialized cell-cell junctions such as adherens junctions (AJs) and tight junctions (TJs). AJs regulate not only the integrity of endothelium through EC-EC adhesion, but also the proliferation and survival of ECs, paracellular permeability to solute, and transmigration of leukocytes across endothelium. TJs play an important role in regulating paracellular permeability and maintaining cell polarity, serving as a barrier and a fence within the membrane. Confluent endothelial cells in culture are generally regarded as a model of resting endothelium in blood vessel, as they form junctions at the points of cell-cell contact, lose ability to proliferate in response to growth factors, and stay stationary. However, incompatibility between junctional integrity and endothelial cell motility remains uncertain. In this study, I try to identify the compatibility between EC adhesion and integrity by time-lapse analysis.","subitem_description_language":"en","subitem_description_type":"Other"}]},"item_14_dissertation_number_75":{"attribute_name":"学位授与番号","attribute_value_mlt":[{"subitem_dissertationnumber":"甲第1583号"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学","subitem_publisher_language":"ja"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_language":"ja","subitem_text_value":"甲博医第1583号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"郭, 仁勇","creatorNameLang":"ja"},{"creatorName":"カク, ジンユウ","creatorNameLang":"ja-Kana"},{"creatorName":"Guo, Renyong","creatorNameLang":"en"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"22-1583.pdf","filesize":[{"value":"4.9 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"22-1583.pdf","url":"https://kumadai.repo.nii.ac.jp/record/21547/files/22-1583.pdf"},"version_id":"cff610b3-95fb-4f74-b60c-fa6d0255695a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"内皮細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"細胞接着","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"胚性幹細胞","subitem_subject_language":"ja","subitem_subject_scheme":"Other"},{"subitem_subject":"タイムラプス解析","subitem_subject_language":"ja","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"The study on the adhesion and motility of endothelial cells derived from embryonic stem cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The study on the adhesion and motility of endothelial cells derived from embryonic stem cells","subitem_title_language":"en"},{"subitem_title":"胚性幹細胞由来内皮細胞における接着と運動に関する研究","subitem_title_language":"ja"},{"subitem_title":"ハイセイ カンサイボウ ユライ ナイヒ サイボウ ニ オケル セッチャク ト ウンドウ ニ カンスル ケンキュウ","subitem_title_language":"ja-Kana"}]},"item_type_id":"14","owner":"127","path":["349"],"pubdate":{"attribute_name":"PubDate","attribute_value":"2014-08-13"},"publish_date":"2014-08-13","publish_status":"0","recid":"21547","relation_version_is_last":true,"title":["The study on the adhesion and motility of endothelial cells derived from embryonic stem cells"],"weko_creator_id":"127","weko_shared_id":-1},"updated":"2026-01-08T00:27:09.560357+00:00"}