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ヒト尿路上皮癌における B7-H1 の発現は WHO grade および術後予後と有意に関係する
http://hdl.handle.net/2298/8303
http://hdl.handle.net/2298/83038d91bece-dbbc-4147-ad49-7a9644a22613
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
22-1591.pdf (3.0 MB)
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| Item type | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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| 公開日 | 2014-08-12 | |||||||||||
| タイトル | ||||||||||||
| タイトル | ヒト尿路上皮癌における B7-H1 の発現は WHO grade および術後予後と有意に関係する | |||||||||||
| 言語 | ja | |||||||||||
| タイトル | ||||||||||||
| タイトル | ヒト ニョウロ ジョウヒ ガン ニ オケル B7-H1 ノ ハツゲン ワ WHO grade オヨビ ジュツゴ ヨゴ ト ユウイ ニ カンケイ スル | |||||||||||
| 言語 | ja-Kana | |||||||||||
| タイトル | ||||||||||||
| タイトル | Overexpression of B7-H1 significantly associates with tumor grade and postoperative prognosis in human urothelial cancers | |||||||||||
| 言語 | en | |||||||||||
| 言語 | ||||||||||||
| 言語 | jpn | |||||||||||
| キーワード | ||||||||||||
| 主題 | PD-1, B7-H1 腫瘍免疫, 腫瘍, 免疫 |
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| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||||||||
| 資源タイプ | thesis | |||||||||||
| 著者 |
仲西, 寿朗
× 仲西, 寿朗
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| 内容記述 | ||||||||||||
| 内容記述 | The programmed death-1 (PD-1)/B7-H1 (also called PD-L1) pathway negatively regulates T-cell activation and has been suggested to play an important role in regulating antitumor host immunity. To investigate the clinical significance of B7-H1 expression to the tumor grade and postoperative prognosis of patients with urothelial cancer, we analyzed the relationship between B7-H1 expression and various clinicopathological features and postoperative prognosis. B7-H1 expression in tumors and the numbers and phenotypes of tumor-infiltrating lymphocytes were evaluated by immunohistochemistry and flow cytometry. A substantial expression of B7-H1 was observed in all urothelial cancers investigated. Tumor specimens from patients with higher WHO grade or primary tumor classifications showed significantly higher percentages of tumor-associated B7-H1. Tumor-associated B7-H1 expression was significantly associated with a high frequency of postoperative recurrence and poor survival rate. Furthermore, multivariate analysis indicated that tumor-associated B7-H1 was more significant prognostic factor than WHO grade. In conclusion, our results demonstrate that the aberrant expression of B7-H1 in urothelial cancer is associated with aggressive tumors, suggesting a regulatory role of tumor-associated B7-H1 in antitumor immunity. |
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| 書誌情報 |
発行年 2007-03-27 |
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| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 日本十進分類法 | ||||||||||||
| 主題 | 377.5 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 熊本大学 | |||||||||||
| 言語 | ja | |||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士（医学）(ja) | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関名 | 熊本大学 | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2007-03-27 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第1591号 | |||||||||||
| 学位番号 | ||||||||||||
| 値 | 甲博医第1591号 | |||||||||||
