{"created":"2023-06-19T09:10:06.398603+00:00","id":21570,"links":{},"metadata":{"_buckets":{"deposit":"959261ed-b8cb-4936-847f-5bf953b3e322"},"_deposit":{"created_by":1,"id":"21570","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"21570"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00021570","sets":["343:344:345:346"]},"author_link":["92685"],"item_14_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"Regulation of CaMKII by α4, a PP2A regulator, contributes to learning and memory"}]},"item_14_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"タンパクシツ ダツ リンサンカ コウソ PP2A セイギョ ブンシ α4 ノ サイボウ チョウセツ キノウ : ノウ ニ オケル CaMKII カッセイ チョウセツ ト ガクシュウ キオク ニ カンスル ケンキュウ"}]},"item_14_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-03-14","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_14_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"山下, 武士","creatorNameLang":"ja"},{"creatorName":"ヤマシタ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamashita, Takeshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"山下","familyNameLang":"ja"},{"familyName":"ヤマシタ","familyNameLang":"ja-Kana"},{"familyName":"Yamashita","familyNameLang":"en"}],"givenNames":[{"givenName":"武士","givenNameLang":"ja"},{"givenName":"タケシ","givenNameLang":"ja-Kana"},{"givenName":"Takeshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92685","nameIdentifierScheme":"WEKO"}]}]},"item_14_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"application/pdf","subitem_description_type":"Other"},{"subitem_description":"text/plain","subitem_description_type":"Other"}]},"item_14_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"学位論文(Thesis)","subitem_description_type":"Other"}]},"item_14_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"α4, a signal transduction molecule, associates directly with the catalytic subunit of protein phosphatase 2A (PP2Ac) and regulates its enzymatic activity. The downstream molecules of α4/PP2Ac remain unclear. It is one of the reasons that the gene targeting of α4 was emblionic lethal. Then, conditional gene targeting of a4 has been analyzed. Conditional gene targeting of\nα4 in B or T lymphocytes demonstrated that α4 played a pivotal role in the proliferation and the differentiation of lymphocytes. It is thought that α4 plays an important role in the neuronal cells because α4-b, an α4 -related molecule, is selectively expressed in the brain and testis, and PP2Ac is abundantly expressed in the brain. In addition, it is expected that the function of α4 is able to be made clearer by deleting α4 gene in α4-b expressing neuronal cells. So, to investigate the neuron specific function of α4, α4 gene was deleted in the neronal cells (N-α4 KO mouse) by conditional gene targeting in this research.","subitem_description_type":"Other"}]},"item_14_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_14_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"377.5","subitem_subject_scheme":"NDC"}]},"item_14_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"61006 bytes"},{"subitem_text_value":"7996418 bytes"},{"subitem_text_value":"100677 bytes"}]},"item_14_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"博士論文"}]},"item_14_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Thesis or Dissertation"}]},"item_14_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_14_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"03"}]},"item_14_text_81":{"attribute_name":"学位番号","attribute_value_mlt":[{"subitem_text_value":"乙博医第901号"}]},"item_14_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"山下, 武士","creatorNameLang":"ja"},{"creatorName":"ヤマシタ, タケシ","creatorNameLang":"ja-Kana"},{"creatorName":"Yamashita, Takeshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"山下","familyNameLang":"ja"},{"familyName":"ヤマシタ","familyNameLang":"ja-Kana"},{"familyName":"Yamashita","familyNameLang":"en"}],"givenNames":[{"givenName":"武士","givenNameLang":"ja"},{"givenName":"タケシ","givenNameLang":"ja-Kana"},{"givenName":"Takeshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92685","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"32-901.pdf","filesize":[{"value":"8.0 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"32-901.pdf","url":"https://kumadai.repo.nii.ac.jp/record/21570/files/32-901.pdf"},"version_id":"4d1c18a4-958c-480a-827f-3cdbc6dc0554"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"α4","subitem_subject_scheme":"Other"},{"subitem_subject":"PP2A","subitem_subject_scheme":"Other"},{"subitem_subject":"ラパマイシン","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"thesis","resourceuri":"http://purl.org/coar/resource_type/c_46ec"}]},"item_title":"タンパク質脱リン酸化酵素 PP2A 制御分子 α4 の細胞調節機能 : 脳における CaMKII 活性調節と学習記憶に関する研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"タンパク質脱リン酸化酵素 PP2A 制御分子 α4 の細胞調節機能 : 脳における CaMKII 活性調節と学習記憶に関する研究"}]},"item_type_id":"14","owner":"1","path":["346"],"pubdate":{"attribute_name":"公開日","attribute_value":"2014-08-13"},"publish_date":"2014-08-13","publish_status":"0","recid":"21570","relation_version_is_last":true,"title":["タンパク質脱リン酸化酵素 PP2A 制御分子 α4 の細胞調節機能 : 脳における CaMKII 活性調節と学習記憶に関する研究"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-09-13T06:05:32.214764+00:00"}