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Expression patterns of epiplakin1 in pancreas,pancreatic cancer and regenerating pancreas
http://hdl.handle.net/2298/11001
http://hdl.handle.net/2298/1100107186b45-de9e-4245-9156-59588c948373
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
TY_manuscriptＧＴＣ.pdf (2.4 MB)
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| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2009-02-27 | |||||
| タイトル | ||||||
| タイトル | Expression patterns of epiplakin1 in pancreas,pancreatic cancer and regenerating pancreas | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| 著者 |
吉田, 哲
× 吉田, 哲× 白木, 伸明× Baba, Hideo× Goto, Mizuki× Fujiwara, Sakuhei× 粂, 和彦× Kume, Shoen |
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| 別言語の著者 |
粂, 昭苑
× 粂, 昭苑× 粂, 和彦 |
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| 内容記述 | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | Epiplakin1 (Eppk1) is a plakin family gene with its function remains largely unknown, although the plakin genes are known to function in interconnecting cytoskeletal filaments and anchoring them at plasma membrane-associated adhesive junction. Here we analyzed the expression patterns of Eppk1 in the developing and adult pancreas in the mice. In the embryonic pancreas, Eppk1+/Pdx1+ and Eppk1+/Sox9+ pancreatic progenitor cells were observed in early pancreatic epithelium. Since Pdx1 expression overlapped with that of Sox9 at this stage, these multipotent progenitor cells are Eppk1+/Pdx1+/Sox9+ cells. Then Eppk1 expression becomes confined to Ngn3+ or Sox9+ endocrine progenitor cells, and p48+ exocrine progenitor cells, and then restricted to the duct cells and a cells at birth. In the adult pancreas, Eppk1 is expressed in centroacinar cells (CACs) and in duct cells. Eppk1 is observed in pancreatic intraepithelial neoplasia (PanIN), previously identified as pancreatic ductal adenocarcinoma (PDAC) precursor lesions. In addition, the expansion of Eppk1-positive cells occurs in a caerulein-induced acute pancreatitis, an acinar cell regeneration model. Furthermore, in the partial pancreatectomy (Px) regeneration model using mice, Eppk1 is expressed in "ducts in foci", a tubular structure transiently induced. These results suggest that Eppk1 serves as a useful marker for detecting pancreatic progenitor cells in developing and regenerating pancreas. | |||||
| 書誌情報 |
Genes to cells 巻 13, 号 7, p. 667-678, 発行年 2008-07 |
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| 書誌レコードID | ||||||
| 収録物識別子タイプ | NCID | |||||
| 収録物識別子 | AA11623816 | |||||
| DOI | ||||||
| 関連タイプ | isVersionOf | |||||
| 関連識別子 | 10.1111/j.1365-2443.2008.01196.x | |||||
| 権利 | ||||||
| 権利情報 | ©2008 by the Molecular Biology Society of Japan/Blackwell Publishing | |||||
| 情報源(ISSN) | ||||||
| 関連名称 | 13652443 | |||||
| フォーマット | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | application/pdf | |||||
| 形態 | ||||||
| 値 | 2391695 bytes | |||||
| 著者版フラグ | ||||||
| 出版タイプ | AM | |||||
| 出版タイプResource | http://purl.org/coar/version/c_ab4af688f83e57aa | |||||
| 日本十進分類法 | ||||||
| 主題Scheme | NDC | |||||
| 主題 | 460 | |||||
| 出版者 | ||||||
| 出版者 | Blackwell Publishing | |||||
| 資源タイプ | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 論文(Article) | |||||
| 資源タイプ・ローカル | ||||||
| 値 | 雑誌掲載論文 | |||||
| 資源タイプ・NII | ||||||
| 値 | Journal Article | |||||
| 資源タイプ・DCMI | ||||||
| 値 | text | |||||
| 資源タイプ・ローカル表示コード | ||||||
| 値 | 01 | |||||
| 著作の一部 | ||||||
| 関連名称 | http://www3.interscience.wiley.com/journal/118514823/home | |||||
