WEKO3
アイテム
水チャンネル aquaporin の機能調節機構に関する研究
http://hdl.handle.net/2298/8701
http://hdl.handle.net/2298/8701b334f7d7-27da-4626-a24e-c98c84eaaa66
| 名前 / ファイル | ライセンス | アクション |
|---|---|---|
23-0137.pdf (2.2 MB)
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| アイテムタイプ | 学位論文 / Thesis or Dissertation(1) | |||||||||||
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| 公開日 | 2014-12-11 | |||||||||||
| タイトル | ||||||||||||
| タイトル | 水チャンネル aquaporin の機能調節機構に関する研究 | |||||||||||
| 言語 | ja | |||||||||||
| タイトル | ||||||||||||
| タイトル | ミズチャンネル aquaporin ノ キノウ チョウセツ ニ カンスル ケンキュウ | |||||||||||
| 言語 | ja-Kana | |||||||||||
| タイトル | ||||||||||||
| タイトル | Study fo Functional Regulation of Water Channel, Aquaporin | |||||||||||
| 言語 | en | |||||||||||
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| 言語 | jpn | |||||||||||
| キーワード | ||||||||||||
| 主題 | AQP 五苓散, 細胞膜水透過性, ニトロソ化 |
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| 資源タイプ | ||||||||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_46ec | |||||||||||
| 資源タイプ | thesis | |||||||||||
| 著者 |
長井, 一史
× 長井, 一史
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| 内容記述 | ||||||||||||
| 内容記述 | Aquaporins (AQPs) are a family of water channel proteins that allow the rapid movement of water in response to osmotic gradients. To date, 13 homologous members of the AQP family have been identified and they are expressed in various organs. Phenotype studies of transgenic AQP knockout mouse models have demonstrated essential roles for AQP in mammalian physiology and pathophysiology. For instance, mice lacking AQPs that are expressed in kidney are polyuric because they were unable to concentrate their urine. AQP5 is expressed in exocrine glands and alveolar type I cells. AQP5-deficient mice exhibit reduced secretion of saliva, sweat and airway fluids. AQP4 is expressed in astrocyte endfeet in the brain. AQP4-deficient mice show reduced traumatic brain injury-induced cerebral edema. Consequently, these studies have been suggested that AQPs are potential targets for new diuretic reagents and novel drugs for disorders that involve water movement, such as brain edema and abnormal airway secretion. However, the functional regulation of AQP has not been fully understood and the clinical modulators of AQP have not been identified. Therefore, in this study, to find new modulators of AQPs, I examined the effects of kampo medicine, various metals and nitric oxide on AQP activity. |
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| 書誌情報 |
発行年 2007-03-27 |
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| 著者版フラグ | ||||||||||||
| 出版タイプ | VoR | |||||||||||
| 出版タイプResource | http://purl.org/coar/version/c_970fb48d4fbd8a85 | |||||||||||
| 日本十進分類法 | ||||||||||||
| 主題 | 377.5 | |||||||||||
| 出版者 | ||||||||||||
| 出版者 | 熊本大学 | |||||||||||
| 言語 | ja | |||||||||||
| 学位名 | ||||||||||||
| 学位名 | 博士（薬学）(ja) | |||||||||||
| 学位授与機関 | ||||||||||||
| 学位授与機関名 | 熊本大学 | |||||||||||
| 学位授与年月日 | ||||||||||||
| 学位授与年月日 | 2007-03-27 | |||||||||||
| 学位授与番号 | ||||||||||||
| 学位授与番号 | 甲第137号 | |||||||||||
| 学位番号 | ||||||||||||
| 値 | 甲博薬第137号 | |||||||||||
