{"created":"2023-06-19T09:10:07.804695+00:00","id":21597,"links":{},"metadata":{"_buckets":{"deposit":"4cbd56ef-291e-4e4d-9c2f-6358996c9e3c"},"_deposit":{"created_by":1,"id":"21597","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"21597"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00021597","sets":["413:443"]},"author_link":["92860","92863","150497","92861","92862"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1997-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"351","bibliographicPageStart":"343","bibliographicVolumeNumber":"42","bibliographic_titles":[{"bibliographic_title":"Japanese Journal of Human Genetics"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Nerve growth factor (NGF) induces neurite outgrowth and promotes survival of embryonic sensory and sympathetic neurons. TRKA, a receptor tyrosine kinase cloned from a human colon cancer was later found to be expressed in the nervous system and phosphorylated in response to NGF. Somatic rearrangement(s) of the TRKA gene (also designated NTRK1) are responsible for formation of some oncogenes. Genetic defects in TRKA are responsible for a human disorder, congenital insensitivity to pain with anhidrosis (CIPA). We report here isolation and characterization of the TRKA gene which spans at least 23 kb and is split into 17 exons. Exon sizes range from 18 to 394 bp and intron sizes range from 170 bp to at least 3.3 kb. Sizes and boundaries of the exons were determined, and all the splice donor and acceptor sites conformed to the GT/AG rule. Approximately 1.2 kb of the 5'-flanking regions was sequenced, and putative regulatory elements were identified. These results will be useful for studies on the developmental and biological regulation of the TRKA gene and for further characterization of mutations in CIPA patients as well as elucidation of mechanisms responsible for rearrangement(s) observed in human tumors.","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Japan Society of Human Genetics"},{"subitem_publisher":"Springer Verlag"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://doi.org/10.1007/bf02766957","subitem_relation_type_select":"DOI"}}]},"item_16_relation_16":{"attribute_name":"情報源(ISSN)","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"09168478"}]}]},"item_16_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10830349","subitem_source_identifier_type":"NCID"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.937","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"280678 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Yasuhiro"}],"nameIdentifiers":[{"nameIdentifier":"92860","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Mardy, Sek","creatorNameLang":"en"}],"familyNames":[{"familyName":"Mardy","familyNameLang":"en"}],"givenNames":[{"givenName":"Sek","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92861","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Tsuruta, Motoko","creatorNameLang":"en"}],"familyNames":[{"familyName":"Tsuruta","familyNameLang":"en"}],"givenNames":[{"givenName":"Motoko","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92862","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"Karim, Mohammad Azharul","creatorNameLang":"en"}],"familyNames":[{"familyName":"Karim","familyNameLang":"en"}],"givenNames":[{"givenName":"Mohammad Azharul","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"92863","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"松田, 一郎","creatorNameLang":"ja"},{"creatorName":"マツダ, イチロウ","creatorNameLang":"ja-Kana"},{"creatorName":"Matsuda, Ichiro","creatorNameLang":"en"}],"familyNames":[{"familyName":"松田","familyNameLang":"ja"},{"familyName":"マツダ","familyNameLang":"ja-Kana"},{"familyName":"Matsuda","familyNameLang":"en"}],"givenNames":[{"givenName":"一郎","givenNameLang":"ja"},{"givenName":"イチロウ","givenNameLang":"ja-Kana"},{"givenName":"Ichiro","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"150497","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Reposit-JJHG-97YI.pdf","filesize":[{"value":"280.7 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Reposit-JJHG-97YI.pdf","url":"https://kumadai.repo.nii.ac.jp/record/21597/files/Reposit-JJHG-97YI.pdf"},"version_id":"98320dbb-1adf-436e-b190-db2a8143bf6a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"先天性無痛無汗症","subitem_subject_scheme":"Other"},{"subitem_subject":"遺伝性感覚自律神経性ニューロパシー IV 型","subitem_subject_scheme":"Other"},{"subitem_subject":"神経成長因子","subitem_subject_scheme":"Other"},{"subitem_subject":"神経成長因子受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"チロシンキナーゼ型神経成長因子受容体","subitem_subject_scheme":"Other"},{"subitem_subject":"TRKA 遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"NTRK1 遺伝子","subitem_subject_scheme":"Other"},{"subitem_subject":"congenital insensitivity to pain with anhidrosis","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"hereditary sensory and autonomic neuropathy type IV","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nerve growth factor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NGF","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"nerve growth factor receptor","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"receptor tyrosine kinase for NGF","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"TRKA gene","subitem_subject_language":"en","subitem_subject_scheme":"Other"},{"subitem_subject":"NTRK1 gene","subitem_subject_language":"en","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Structure and organization of the human TRKA gene encoding a high affinity receptor for nerve growth factor","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Structure and organization of the human TRKA gene encoding a high affinity receptor for nerve growth factor"}]},"item_type_id":"16","owner":"1","path":["443"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-08-07"},"publish_date":"2008-08-07","publish_status":"0","recid":"21597","relation_version_is_last":true,"title":["Structure and organization of the human TRKA gene encoding a high affinity receptor for nerve growth factor"],"weko_creator_id":"1","weko_shared_id":1},"updated":"2023-09-13T06:59:51.213973+00:00"}