{"created":"2023-06-19T09:10:15.836005+00:00","id":21761,"links":{},"metadata":{"_buckets":{"deposit":"e3e94943-e9eb-4076-8a1a-970bfb951036"},"_deposit":{"created_by":1,"id":"21761","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"21761"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00021761","sets":["413:429"]},"author_link":["94226","94224","94225"],"item_18_alternative_title_23":{"attribute_name":"タイトル（ヨミ）","attribute_value_mlt":[{"subitem_alternative_title":"シンセダイ アデノウイルスベクター ト トランスポゼース ニ ヨル シンコウセイ キン ジストロフィー ノ イデンシ チリョウ"}]},"item_18_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03-31","bibliographicIssueDateType":"Issued"},"bibliographic_titles":[{}]}]},"item_18_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Uchino, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"94226","nameIdentifierScheme":"WEKO"}]}]},"item_18_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf"}]},"item_18_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"研究報告書","subitem_description_type":"Other"}]},"item_18_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Using HDAdv, we could treat DMD model mice, even when the therapeutic gene was transferred into multiple skeletal muscles. Our results suggest that multiple intramuscular administrations of HDAdv carrying full-length dystrophin may reduce symptoms and compensate for lost functions in DMD patients.\nFor the long expression of target gene product, we tried to integrate the dystrophin gene into chromosome by using the sleeping beauty-transposone system and HDAdv. However, ito revealed that the DNA construct of HDAdv is linear and it does not fit the circular DNA of the sleeping buauty-transposone system. So, further study is necessary to integrate the dystrophin gene into chromosome.","subitem_description_type":"Other"}]},"item_18_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_18_relation_61":{"attribute_name":"関連","attribute_value_mlt":[{"subitem_relation_type":"hasPart","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/2298/10918","subitem_relation_type_select":"URI"}}]},"item_18_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"493.6","subitem_subject_scheme":"NDC"}]},"item_18_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"2137452 bytes"}]},"item_18_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"研究報告書"}]},"item_18_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Research Paper"}]},"item_18_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_18_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"06"}]},"item_18_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_value":"平成18～19年度科学研究費補助金(基盤研究(C)(2))研究成果報告書 課題番号:18590951"},{"subitem_text_value":"報告書内に学術雑誌掲載論文（本文未公開）あり。本文公開論文については関連を参照"}]},"item_18_text_80":{"attribute_name":"科研費番号","attribute_value_mlt":[{"subitem_text_value":"18590951"}]},"item_18_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"VoR"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"内野, 誠"}],"nameIdentifiers":[{"nameIdentifier":"94224","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"KaC218590951.pdf","filesize":[{"value":"2.1 MB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"KaC218590951.pdf","url":"https://kumadai.repo.nii.ac.jp/record/21761/files/KaC218590951.pdf"},"version_id":"a05ea1ab-10c3-48fc-88c4-c3d0f20527cb"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"dystrophin","subitem_subject_scheme":"Other"},{"subitem_subject":"hleper-dependent adenovirs","subitem_subject_scheme":"Other"},{"subitem_subject":"dkoマウス","subitem_subject_scheme":"Other"},{"subitem_subject":"multiple muscle injection","subitem_subject_scheme":"Other"},{"subitem_subject":"Sleeping Beauty transposon","subitem_subject_scheme":"Other"},{"subitem_subject":"dko mouse","subitem_subject_scheme":"Other"},{"subitem_subject":"nNOS","subitem_subject_scheme":"Other"},{"subitem_subject":"hepler-dependent adenovirus vector","subitem_subject_scheme":"Other"},{"subitem_subject":"genetherapy","subitem_subject_scheme":"Other"},{"subitem_subject":"Duchenne muscular dystrophy","subitem_subject_scheme":"Other"},{"subitem_subject":"DMD","subitem_subject_scheme":"Other"},{"subitem_subject":"mdx mouse","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"research report","resourceuri":"http://purl.org/coar/resource_type/c_18ws"}]},"item_title":"新世代アデノウイルスベクターとトランスポゼースによる進行性筋ジストロフィーの遺伝子治療","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"新世代アデノウイルスベクターとトランスポゼースによる進行性筋ジストロフィーの遺伝子治療"}]},"item_type_id":"18","owner":"1","path":["429"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-11-04"},"publish_date":"2008-11-04","publish_status":"0","recid":"21761","relation_version_is_last":true,"title":["新世代アデノウイルスベクターとトランスポゼースによる進行性筋ジストロフィーの遺伝子治療"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-06-19T19:07:13.196335+00:00"}