{"created":"2023-06-19T09:10:16.842468+00:00","id":21778,"links":{},"metadata":{"_buckets":{"deposit":"96af52f7-c684-43ac-bd1f-017e69d70818"},"_deposit":{"created_by":1,"id":"21778","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"21778"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00021778","sets":["399:436"]},"author_link":["147576"],"item_18_alternative_title_22":{"attribute_name":"その他の言語のタイトル","attribute_value_mlt":[{"subitem_alternative_title":"ラット コッカクキン センイ タイプ ト サイズ ニ タイスル アポトーシス カンレン タンパクシツ ノ 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回復群(HU)とHU+CsA投与回復群(HU+CsA)に分け、2週間の後肢懸垂を行った後、回復0日、3日、7日、14日にそれぞれ下肢よりヒラメ筋を摘出した。,免疫組織染色により、筋核数、アポトーシス核数、筋線維横断面積の変化を検討した。またウェスタンブロットにより、各種タンパク質の変化を分析した。\n研究結果と考察:後肢懸垂により筋線維横断面積は73%低下したが、回復14日間でCon群の90%近くまで回復した。一方、 HU+CsA群の横断面積は、回復14日目においても他のぐんと比較して有意に低く、このことから筋線維サイズの増加にはカルシニューリンが関与することが示唆された。筋核数は後肢懸垂により有意に減少し、これはアポトーシス核の増加による核の除去が原因であると思われた。回復14日間でアポトーシス核数は顕著に減少し、これに伴い筋核数もConレベルまで回復した。熱ショックタンパク質(HSP)72およびカルシニューリン発現量は、後肢懸垂により減少し、回復期にはConレベルまで回復した。","subitem_description_type":"Other"}]},"item_18_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"熊本大学"}]},"item_18_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.363","subitem_subject_scheme":"NDC"}]},"item_18_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"362409 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