{"created":"2023-06-19T09:10:22.112249+00:00","id":21867,"links":{},"metadata":{"_buckets":{"deposit":"aee29623-e11d-4370-ab37-166d86bd0113"},"_deposit":{"created_by":1,"id":"21867","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"21867"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00021867","sets":["415:416"]},"author_link":["94689","94615","94685","94674","94675","94617","94672","94687","94686","94684","94688","94310"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2006-11","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"285","bibliographicPageStart":"279","bibliographicVolumeNumber":"56","bibliographic_titles":[{"bibliographic_title":"Neuroscience Research"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"浜, 康博"}],"nameIdentifiers":[{"nameIdentifier":"94684","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"香月, 博志"}],"nameIdentifiers":[{"nameIdentifier":"94685","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"栃川, 宣永"}],"nameIdentifiers":[{"nameIdentifier":"94686","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"角中, ちひろ"}],"nameIdentifiers":[{"nameIdentifier":"94687","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"久米, 利明"}],"nameIdentifiers":[{"nameIdentifier":"94688","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"赤池, 昭紀"}],"nameIdentifiers":[{"nameIdentifier":"94689","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"N-Methyl-d-aspartate (NMDA) receptors, which play an important role in neuronal excitotoxicity, require not only agonists at the glutamate-binding site but also co-agonists at the glycine site for their activation. Here we examined the role of endogenous agonists at the glycine site of NMDA receptors in excitotoxic retinal damage in vivo. To quantify the number of surviving retinal ganglion cells (RGCs), we injected a retrograde tracer, fluoro-gold, into the superior colliculus bilaterally and subsequently counted RGCs on whole-mounted retinas. Co-injection of 5,7-dichlorokynurenic acid (300 nmol), a competitive antagonist at the glycine site of NMDA receptors, rescued RGCs from damage induced by 200 nmol NMDA. On the other hand, RGC death induced by 20 nmol NMDA was enhanced by addition of glycine (10 nmol), d-serine (10 nmol) or a competitive glycine transporter-1 inhibitor, sarcosine (0.3 or 3 nmol). Moreover, application of d-serine-degrading enzyme, d-amino acid oxidase (30 mU), partially suppressed RGC death induced by 20 nmol NMDA. These results suggest that the severity of excitotoxic retinal damage in vivo depends on the levels of both glycine and d-serine.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.elsevier.com/wps/find/journaldescription.cws_home/506082/description#description","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Elsevier Ireland Ltd"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.neures.2006.07.008","subitem_relation_type_select":"DOI"}}]},"item_16_relation_60":{"attribute_name":"部分である","attribute_value_mlt":[{"subitem_relation_type":"isPartOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/2298/9868","subitem_relation_type_select":"URI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2006 Elsevier Ireland Ltd and the Japan Neuroscience Society All rights reserved."}]},"item_16_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"01680102","subitem_source_identifier_type":"ISSN"}]},"item_16_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA10641652","subitem_source_identifier_type":"NCID"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.17","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"305384 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_16_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_16_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_16_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_value":"平成18～19年度科学研究費補助金(基盤研究(C))研究成果報告書 課題番号:18590052『ミクログリアの活性化を介する黒質線条体系ニューロン変性の機序とその防御』pp.65-71に掲載"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hama, Yasuhiro"}],"nameIdentifiers":[{"nameIdentifier":"94672","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"香月, 博志","creatorNameLang":"ja"},{"creatorName":"カツキ, ヒロシ","creatorNameLang":"ja-Kana"},{"creatorName":"Katsuki, Hiroshi","creatorNameLang":"en"}],"familyNames":[{"familyName":"香月","familyNameLang":"ja"},{"familyName":"カツキ","familyNameLang":"ja-Kana"},{"familyName":"Katsuki","familyNameLang":"en"}],"givenNames":[{"givenName":"博志","givenNameLang":"ja"},{"givenName":"ヒロシ","givenNameLang":"ja-Kana"},{"givenName":"Hiroshi","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94310","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tochikawa, Yoshinaga"}],"nameIdentifiers":[{"nameIdentifier":"94674","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suminaka, Chihiro"}],"nameIdentifiers":[{"nameIdentifier":"94675","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"久米, 利明","creatorNameLang":"ja"},{"creatorName":"クメ, トシアキ","creatorNameLang":"ja-Kana"},{"creatorName":"Kume, Toshiaki","creatorNameLang":"en"}],"familyNames":[{"familyName":"久米","familyNameLang":"ja"},{"familyName":"クメ","familyNameLang":"ja-Kana"},{"familyName":"Kume","familyNameLang":"en"}],"givenNames":[{"givenName":"利明","givenNameLang":"ja"},{"givenName":"トシアキ","givenNameLang":"ja-Kana"},{"givenName":"Toshiaki","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94615","nameIdentifierScheme":"WEKO"}]},{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"赤池, 昭紀","creatorNameLang":"ja"},{"creatorName":"アカイケ, アキノリ","creatorNameLang":"ja-Kana"},{"creatorName":"Akaike, Akinori","creatorNameLang":"en"}],"familyNames":[{"familyName":"赤池","familyNameLang":"ja"},{"familyName":"アカイケ","familyNameLang":"ja-Kana"},{"familyName":"Akaike","familyNameLang":"en"}],"givenNames":[{"givenName":"昭紀","givenNameLang":"ja"},{"givenName":"アキノリ","givenNameLang":"ja-Kana"},{"givenName":"Akinori","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"94617","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2020-03-02"}],"displaytype":"detail","filename":"Neu Res0056-0279.pdf","filesize":[{"value":"305.4 kB"}],"format":"application/pdf","licensetype":"license_note","mimetype":"application/pdf","url":{"label":"Neu Res0056-0279.pdf","url":"https://kumadai.repo.nii.ac.jp/record/21867/files/Neu Res0056-0279.pdf"},"version_id":"700278c8-8461-42f4-aa7c-daadcb6c664a"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Apoptosis","subitem_subject_scheme":"Other"},{"subitem_subject":"Excitotoxicity","subitem_subject_scheme":"Other"},{"subitem_subject":"Ganglion cell","subitem_subject_scheme":"Other"},{"subitem_subject":"Glutamate","subitem_subject_scheme":"Other"},{"subitem_subject":"Neuronal death","subitem_subject_scheme":"Other"},{"subitem_subject":"Retina","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo"}]},"item_type_id":"16","owner":"1","path":["416"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-12-02"},"publish_date":"2008-12-02","publish_status":"0","recid":"21867","relation_version_is_last":true,"title":["Contribution of endogenous glycine site NMDA agonists to excitotoxic retinal damage in vivo"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-09-26T01:17:14.075226+00:00"}