{"created":"2023-06-19T09:10:22.157746+00:00","id":21868,"links":{},"metadata":{"_buckets":{"deposit":"0fdd26ee-0f96-4cf3-9afd-ca9a5c6e30e3"},"_deposit":{"created_by":1,"id":"21868","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"21868"},"status":"published"},"_oai":{"id":"oai:kumadai.repo.nii.ac.jp:00021868","sets":["415:480"]},"author_link":["94615","94692","94707","94705","94703","94693","94626","94617","94704","94706","94702","94310"],"item_16_biblio_info_6":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2007-01-19","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"701","bibliographicPageStart":"694","bibliographicVolumeNumber":"144","bibliographic_titles":[{"bibliographic_title":"Neuroscience"}]}]},"item_16_creator_3":{"attribute_name":"別言語の著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"藤本, 真二"}],"nameIdentifiers":[{"nameIdentifier":"94702","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"香月, 博志"}],"nameIdentifiers":[{"nameIdentifier":"94703","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"大西, 正俊"}],"nameIdentifiers":[{"nameIdentifier":"94704","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"高木, 美佳子"}],"nameIdentifiers":[{"nameIdentifier":"94705","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"久米, 利明"}],"nameIdentifiers":[{"nameIdentifier":"94706","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"赤池, 昭紀"}],"nameIdentifiers":[{"nameIdentifier":"94707","nameIdentifierScheme":"WEKO"}]}]},"item_16_description_17":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_16_description_46":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"subitem_description":"論文(Article)","subitem_description_type":"Other"}]},"item_16_description_5":{"attribute_name":"内容記述","attribute_value_mlt":[{"subitem_description":"Intracerebral hemorrhage represents stroke characterized by formation and expansion of hematoma within brain parenchyma. Blood-derived factors released from hematoma are considered to be involved in poor prognosis of this disorder. We previously reported that thrombin, a blood-derived serine protease, induced cytotoxicity in the cerebral cortex and the striatum in organotypic slice cultures, which depended on mitogen-activated protein kinase (MAPK) pathways. Here we investigated the mechanisms of thrombin cytotoxicity in the striatum in vivo. Thrombin microinjected into the striatum of adult rats induced neuronal death and microglial activation around the injection site. Neuronal loss without any sign of nuclear fragmentation was observed as early as 4 h after thrombin injection, which was followed by gradual neuronal death exhibiting nuclear fragmentation. Thrombin-induced damage assessed at 72 h after injection was partially but significantly reduced by concomitant administration of inhibitors of MAPK pathways. Activation of extracellular signal-regulated kinase (ERK) and p38 MAPK in response to thrombin was verified by Western blot analysis. Moreover, phosphorylated ERK and p38 MAPK were localized prominently in reactive microglia, and inhibition of microglial activation by minocycline attenuated thrombin-induced damage, suggesting that reactive microglia were responsible for thrombin-induced neuronal death. Thus, MAPK pathways and microglial activation may serve as therapeutic targets of pathogenic conditions associated with hemorrhagic stroke.","subitem_description_type":"Other"}]},"item_16_description_77":{"attribute_name":"URL","attribute_value_mlt":[{"subitem_description":"http://www.elsevier.com/wps/find/journaldescription.cws_home/468/description#description","subitem_description_type":"Other"}]},"item_16_publisher_36":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Brain Research Organization"}]},"item_16_relation_11":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type":"isVersionOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.neuroscience.2006.09.049","subitem_relation_type_select":"DOI"}}]},"item_16_relation_60":{"attribute_name":"部分である","attribute_value_mlt":[{"subitem_relation_type":"isPartOf","subitem_relation_type_id":{"subitem_relation_type_id_text":"http://hdl.handle.net/2298/9868","subitem_relation_type_select":"URI"}}]},"item_16_rights_12":{"attribute_name":"権利","attribute_value_mlt":[{"subitem_rights":"© 2006 IBRO Published by Elsevier Ltd."}]},"item_16_source_id_7":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"03064522","subitem_source_identifier_type":"ISSN"}]},"item_16_source_id_9":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA0075489X","subitem_source_identifier_type":"NCID"}]},"item_16_subject_20":{"attribute_name":"日本十進分類法","attribute_value_mlt":[{"subitem_subject":"491.17","subitem_subject_scheme":"NDC"}]},"item_16_text_18":{"attribute_name":"形態","attribute_value_mlt":[{"subitem_text_value":"401732 bytes"}]},"item_16_text_47":{"attribute_name":"資源タイプ・ローカル","attribute_value_mlt":[{"subitem_text_value":"雑誌掲載論文"}]},"item_16_text_48":{"attribute_name":"資源タイプ・NII","attribute_value_mlt":[{"subitem_text_value":"Journal Article"}]},"item_16_text_49":{"attribute_name":"資源タイプ・DCMI","attribute_value_mlt":[{"subitem_text_value":"text"}]},"item_16_text_50":{"attribute_name":"資源タイプ・ローカル表示コード","attribute_value_mlt":[{"subitem_text_value":"01"}]},"item_16_text_78":{"attribute_name":"コメント","attribute_value_mlt":[{"subitem_text_value":"平成18～19年度科学研究費補助金(基盤研究(C))研究成果報告書 課題番号:18590052『ミクログリアの活性化を介する黒質線条体系ニューロン変性の機序とその防御』pp.80-87に掲載"}]},"item_16_version_type_19":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorAffiliations":[{"affiliationNameIdentifiers":[{"affiliationNameIdentifier":"","affiliationNameIdentifierScheme":"ISNI","affiliationNameIdentifierURI":"http://www.isni.org/isni/"}],"affiliationNames":[{"affiliationName":"","affiliationNameLang":"ja"}]}],"creatorNames":[{"creatorName":"藤本, 真二","creatorNameLang":"ja"},{"creatorName":"フジモト, 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mitogen-activated protein kinase pathways in vivo","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Thrombin induces striatal neurotoxicity depending on mitogen-activated protein kinase pathways in vivo"}]},"item_type_id":"16","owner":"1","path":["480"],"pubdate":{"attribute_name":"公開日","attribute_value":"2008-12-02"},"publish_date":"2008-12-02","publish_status":"0","recid":"21868","relation_version_is_last":true,"title":["Thrombin induces striatal neurotoxicity depending on mitogen-activated protein kinase pathways in vivo"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-09-26T01:19:35.793200+00:00"}